Systemic side effects occur as a result of a small amount of the cortisone entering the bloodstream and affecting your entire body, not just the location where the cortisone was given.
Systemic side effects of a local injection of cortisone are rare and usually minor. Unlike taking oral steroids, or having cortisone injected directly into the bloodstream, only a small amount of a local injection is absorbed by the body. And since the body actually produces cortisone naturally, most people do not experience systemic effects. Those who do may experience:

Elevated Blood Sugar
The most common systemic reaction is seen in diabetic patients. Patients with diabetes should carefully monitor their blood sugar as cortisone can cause a temporary rise in their levels. Patients taking insulin should be especially careful, checking their blood sugar often and adjusting the insulin doses, if necessary.
Facial Flushing
Patients may experience flushing sensation and redness of their face. This reaction is more common in women and is seen into up to 15 percent of patients. This can begin within a few hours of the injection and may last for a few days.
Prednisone and hydrocortisone are some of the top drugs used to treat lupus, Crohn’s disease, and other autoimmune or inflammatory conditions and sometimes to treat skin disorders. Unfortunately, they also leach calcium from your body and increase its elimination, putting you at greater risk of bone fracture and osteoporosis. Some studies have shown these drugs can also lower levels of key trace elements, including magnesium, selenium, zinc, copper, and potassium. You should be taking supplements to offset the loss of so many important nutrients.
There are lots of natural herbal equivalents with a high degree of efficacy with no side effects like curcumins, grape seed extract, alpha lipoic acid and glucosamines that act as natural anti inflammatory.
Taking additional calcium, magnesium and Vitamin D3 is recommended if you must take cortisone.
We use the biofeedback device to evaluate the side effects of prescription medication and the overall health of vital key organs.

Author's Bio: 

Dr. George Grant, Ph.D., I.M.D. Specialist in Nutrition, Stress, and Biofeedback.