Martijn Arns Dr.

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Neuromodulation and Personalized Medicine in ADHD and Depression Expert

Martijn Arns Quick Facts

Main Areas: Neuromodulation, Personalized Medicine, Neurofeedback, rTMS, ADHD, Depression
Affiliation: Research Institute Brainclinics / Utrecht University

Martijn Arns graduated in the late 90’s as a biological psychologist at Radboud University in Nijmegen. After several projects in the field of applied neuroscience in the Westmead Hospital in Sydney, the Max Planck Institute in Munich and Organon Research in Newhouse, he began in 2001 with what is now known as Research Institute Brainclinics and Psychologists Practice Brainclinics.

Martijn Arns received his PhD at Utrecht University on the topic of 'EEG-based personalized medicine for ADHD and depression' and is specialized in applying brain imaging techniques to determine the appropriate treatment for patients with ADHD and depression. He is specialized in the development and application of neuromodulation techniques such as neurofeedback in the treatment of ADHD and magnetic brain stimulation (rTMS) in the treatment of depression. Martijn Arns supervises a team of specialized psychologists at Psychology Practice Brainclinics in the application of these techniques. At Research Institute Brainclinics Martijn Arns carries out research into personalized medicine and neuromodulation techniques in collaboration with a team of researchers and various universities. In addition, he teaches several (internationally) accredited training courses such as an ‘rTMS in Depression’ workshop and a ‘Neurofeedback in ADHD’ training course.

Martijn Arns is director at Research Institute Brainclinics and Psychology Practice Brainclinics, is associated with Utrecht University, department of experimental psychology, and was founding director of Brainquiry until July 2007. In addition, Martijn Arns serves on the board of directors of the International Pharmaco-EEC Society (IPEG) and is a member of several professional organizations such as the NIP (Dutch Institute of Psychologists), ISNR, ECNS, SAN, AAAS and ISAD.

For his online CV also see LinkedIn and for a list of publications also see Publications and Presentations

Recent Articles

Promising New Treatment For Depression: Magnetic Brain Stimulation (rTMS)

Free Articles & Book Excerpts

rTMS in Depression

Neurofeedback for ADHD/ADD

Other Programs & Highlights

Some selected publications:

2012

Arns, M., Drinkenburg, W. H. I. M., Fitzgerald, P. B., & Kenemans, J. L. (in press). Neurophysiological predictors of treatment outcome to rtms in depression. Brain Stimulation.

Arns, M., Drinkenburg, W.H.I.M. & Kenemans, J.L. (In Press). The effects of QEEG-informed neurofeedback in ADHD: An open label pilot study. Applied Psychophysiology and Biofeedback.

Arns, M. (In Press). EEG Based Personalized Medicine in ADHD: Individual alpha peak frequency as an endophenotype associated with non-response. Journal of Neurotherapy.

Arns, M. & Kenemans, J.L. (Under Review). Neurofeedback in ADHD, epilepsy and insomnia: Vigilance Stabilization through sleep spindles and circadian networks. Neuroscience and Biobehavioral Reviews.

2011 and earlier

Arns, M. (2011). Personalized medicine in ADHD and depression: A quest for EEG treatment predictors. PhD thesis. PhD thesis, Utrecht University.

Sherlin, L., Arns, M., Lubar, J., & Sokhadze, E. (2010a). A reply to Lofthouse, Arnold, and Hurt (2010). Journal of Neurotherapy, 14(4), 307-311.

Sherlin, L., Arns, M., Lubar, J. F., & Sokhadze, E. (2010b). A position paper on neurofeedback for the treatment of ADHD. Journal of Neurotherapy, 14(2), 66-78.

Arns, M., de Ridder, S., Strehl, U., Breteler, M., & Coenen, A. (2009). Efficacy of neurofeedback treatment in ADHD: The effects on inattention, impulsivity and hyperactivity: A meta-analysis. Clinical EEG and Neuroscience, 40(3), 180-9.

Getting Started With Martijn Arns

Brainclinics was established in 2001 as a research institute specialized in Applied Neuroscience, Neuromodulation, and Personalized Medicine with a focus on ADHD and depression.

Brainclinics conducts applied brain research (Applied Neuroscience) using of techniques such as EEG and QEEG, Event Related Potentials (ERPs) and neuropsychological assessments.

Applied Neuroscience

In the "Applied Neuroscience" section the history of these techniques and a historical review on diagnosis and prognosis of ADHD and Depression are presented. The first section describes the history from EEG to QEEG. The second part further elaborates on the EEG as a biomarker or endophenotype, followed by a historical overview of neurophysiological studies in ADHD and depression and anoverview of models and theories about the interpretation of EEG and QEEG. Finally, some EEG examples for subtypes can be found such as a Low-Voltage EEG and Beta spindles.

Personalized Medicine for ADHD and Depression

In the recent years Brainclinics has specialized to further explore the use of neurophysiological techniques in predicting treatment outcomes to different treatments such as psychostimulants (e.g. Ritalin), antidepressants (e.g. SSRIs), rTMS for depression and Neurofeedback in ADHD. This development is also called Personalized Medicine. Under the section Personalized Medicine and Neuromodulation, more information can be found on the current status of treatment efficacy in psychiatry and new developments in this area. In the section on ADHD a summary of the current state of research on Personalized Medicine in ADHD to various treatments is provided. In addition an explanatory model is proposed explaining how to interpret these different sub-types and how treatments for ADHD may be further improved based on this knowledge. In the section on depression the current status of research on Personalized Medicine for Depression is summarized and two subtypes that predict non-response to antidepressant treatments are described. In this section the possibilities for other treatments for these so-called non-responders are also described. Finally, a specific EEG endophenotype associated with non-response to various conventional treatments such as psychostimulants, antidepressants and rTMS, namely the Alpha Peak Frequency individual (iAPF) is described. This endophenotype is described in more detail and suggestions for potential interventions that deserve further development are described.

iSPOT study of ADHD and Depression

Currently Research Institute Brainclinics is one of the international groups involved in the iSPOT studies, which stands for International Study to Predict Optimised Treatment Response in ADHD (iSPOT-A) and Depression (iSPOT-D). This is the largest ever trial into the potential of Personalized Medicine in more than 2000 depressed patients (who will be prescribed an antidepressant), and more than 500 children with ADHD prescribed with methylphenidate (eg Ritalin).

For this study we are still seeking patients with ADHD or Depression considering to use medication or prepared to change medications. For more information see the section iSPOT.

Research, publications and education

For an overview of scientific publications, book chapters and books published by Brainclinics staff you can consult the Publications section or the Media section to read about the several media appearances of Brainclinics.

Furthermore, Brainclinics also organizes training courses and workshops in the area of Applied Neuroscience and Neuromodulation such as the BCIA accredited Neurofeedback course and rTMS training course. More about these courses can be found underBrainclinics Education and on the bottom of this page some free educational downloads can be found such as various PowerPoint presentations and the PhD dissertation of Martijn Arns on the above topics.