This article was originally posted at http://www.apple-a-day-clinic.com/Health_and_Nutrition_Blog?m8:post=chin...
Traditional Chinese medicine is widely used as a form of complementary medicine all over the world for various indications and for improving general health. Proprietary Chinese medicines (pCMs) -- which are composed solely of Chinese medicines and formulated in a finished dose form -- are generally believed to be natural and safe, but a new analysis in the British Journal of Clinical Pharmacology reveals some serious dangers.
Various reports have documented the adulteration of PCMs and health products with undeclared agents, including prescription drugs, drug analogues, and banned drugs. Such adulteration of products can have serious and even fatal consequences.
To examine the problem, Tony Wing Lai Mak, MBChB, MBA, FRCPath, FRCPA, FHKCPath, FHKAM(Path), Chor Kwan Ching, MBChB, MSc, FRCPA, FHKAM (Pathology), and their colleagues at the only tertiary referral clinical toxicology laboratory in Hong Kong retrospectively reviewed cases involving use of pCMs or health products adulterated with undeclared drugs referred to the center from 2005 to 2015.
The investigators identified 404 cases involving the use of 487 adulterated pCMs or health products with a total of 1,234 adulterants. The adulterants consisted of approved drugs, banned drugs, drug analogues, and animal thyroid tissue. The six most common categories of adulterants detected were nonsteroidal anti-inflammatory drugs (18%), anorectics (15%), corticosteroids (14%), diuretics and laxatives (11%), oral antidiabetic agents (10%), and erectile dysfunction drugs (6%). Sibutramine, an anorectic that has been withdrawn from the market due to its association with increased cardiovascular events and strokes, was the single most common adulterant identified.
The sources of illicit products included over-the-counter drug stores, the Internet, and even some Chinese medicine practitioners. Importantly, 65% of patients experienced adverse effects attributable to these illicit products, including 14 severe and two fatal cases. Psychosis, iatrogenic Cushing syndrome, and hypoglycaemia were the three most frequently encountered adverse effects.
"These illicit pCMs and health products pose severe health hazards to the public," said Dr. Mak. "Previous reports of pCM and health product adulteration were mainly routine surveillance data or case reports/series with a small number of affected patients. The present study, to our knowledge, is the largest case series that reports an overview of the use of various adulterated pCMs and health products and the resulting adverse effects." The take home lesson here is that most Chinese factories are not up to US standards when manufacturing these medicines. You must be careful in obtaining the best medicines possible from very good sources or through a trusted practioner who has had longterm relationships with the manufacturer and knows their standards for quality. I do not advocate purchasing these products through Amazon and other "dumping grounds" as they are often counterfeit products or confiscated products that can be detrimental to health.
Chor Kwan Ching, Sammy Pak Lam Chen, Hencher Han Chih Lee, Ying Hoo Lam, Sau Wah Ng, Mo Lung Chen, Magdalene Huen Yin Tang, Suzanne Suk San Chan, Candy Wai Yan Ng, Jana Wing Lan Cheung, Tina Yee Ching Chan, Nike Kwai Cheung Lau, Yeow Kuan Chong, Tony Wing Lai Mak. Adulteration of Proprietary Chinese Medicines and Health Products with Undeclared Drugs: Experience of a Tertiary Toxicology Laboratory in Hong Kong. British Journal of Clinical Pharmacology, 2017; DOI: 10.1111/bcp.13420
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