Lack of erection or insufficient erection prevent sexual intercourse on a level considered satisfactory. Such a condition is generally referred to as erectile dysfunction and it is estimated that over 150 million men over 35 years of age in the world suffer from it, and as many as 2.5 million in Europe, of which only about 5% undergo treatment. Such a low percentage of people reporting to a specialist may result from the feeling of embarrassment in front of the doctor but also in front of the partner, lack of adequate sexual education and insufficient knowledge about the available treatment methods.
The mechanism of penile erection is the temporary filling of blood in the cavernous bodies of the penis when sexual arousal is felt. In order for blood to flow to the above-mentioned structures, it is necessary to relax the smooth muscles of the corpora cavernosa and to widen the arteries supplying blood to the penis, which causes compression of the intracavernous veins, which is seen as an erection. The whole pattern of reactions begins with the activation of nerve fibers in the parasympathetic system which, through nitric oxide (NO) and cGMP, its secondary messenger, initiate the described cascade.
Erectile dysfunction is a very delicate and complex problem, therefore it is very important for proper treatment to understand the causes of this condition. How many people struggle with this problem, there are so many reasons for its occurrence. The development of these disorders can be caused by both physical and mental factors.
The physical causes of erectile dysfunction include:
malfunction or damage to the cavernous bodies,
improper functioning of the vessels, which results in reduced arterial blood inflow or increased outflow of venous blood, disturbances in the hormonal balance, among them the most important are:
too low testosterone level,
hyperprolactinaemia,
neurological disorders, for example, transverse paralysis.
Concomitant diseases also have a significant impact on the formation of penile erectile dysfunction, such as:
diabetes,
arterial hypertension,
multiple sclerosis,
kidney and heart disease.
Medications for other medical conditions can also make an erection less or weaken. In this context, antidepressants, sedatives, anti-androgenic and antihypertensive drugs are most often referred to. The use of stimulants, alcohol and cigarettes may also be important.
Mental erectile dysfunction can arise when a man feels afraid of having intercourse because he cannot fully have it, has low self-esteem and problems in the relationship he is in at the moment. This situation may also occur when the man is not yet ready to have children and the fear of conceiving a child blocks him internally. There are also much more serious situations where the fear of sexual intercourse is the result of a bad past experience.
The pathophysiology of erectile dysfunction has made it possible to divide these disorders into three basic types:
inability to get an erection,
inability to maintain it,
damage to the filling mechanism of the cavernous bodies.
Due to the fact that it is a disease that affects the sphere of a very delicate and intimate, its diagnosis is usually difficult. It is very important that the patient receives appropriate support and understanding from the medical staff, as well as the doctor or therapist, and that all examinations are accompanied by an atmosphere of intimacy and comfort. Correct diagnosis is based on a thorough interview conducted with the patient during the first visit, followed by a physical examination, which brings the doctor closer to starting the correct treatment.
For the treatment of erectile dysfunction, phosphodiesterase 5 (PDE 5) inhibitors, orally administered sildenafil, tadalafil and vardenafil are typically used. Phosphodiesterase 5 itself is an enzyme responsible for the breakdown of cGMP and cAMP nucleotides, which are messengers in the mechanism of action of many neurohormones. They also participate in the regulation of the contraction of smooth muscles, including the smooth muscles of blood vessels.
All preparations available on the market are characterized by the same mechanism of action, and the differences between them result from different pharmacological properties.
Sildenafil, the major ingredient used in Kamagra was introduced as the first to treat erectile dysfunction and its affinity to type 5 phosphodiesterase is much greater than that of other isoforms. Kamagra is produced by Ajanta pharmaceutical in India, Kamagra is well known for its lower cost compared to other counterparts, and also for it's high effectiveness. <a href=”https://www.kamagraavenue.to/en/products/kamagra”>Kamagra pills</a> are well absorbed from the gastrointestinal tract, but meals, especially those containing large amounts of fat, slow this process. The maximum reaction of the body is observed about 60 minutes after oral ingestion of the drug (it penetrates well into the tissues), and the effect lasts up to 6 hours.
standard doses range from 25 to 100 mg,
however, a dose of 50 mg taken 30 minutes before planned intercourse is usually recommended.
<b>Contraindications to the use of Kamagra are:</b>
heart or liver disease,
stroke,
myocardial infarction within 6 months before the planned use of this drug,
unstable ischemic heart disease.
The drug's limitations include both low and high blood pressure, as well as concurrent use of nitrates or other nitric oxide-producing drugs. These medications can only be given to the patient 24 hours after the last dose of sildenafil.
People with retinitis pigmentosa, leukemia, peptic ulcer disease, or anatomical deformation of the penis should be especially cautious when taking sildenafil-containing medications. The most common side effects of Sildenafil therapy are headache, dizziness, and flushing. Patients may experience dyspeptic symptoms, visual disturbances (photosensitivity), and nasal congestion. A painful erection of the penis is a very dangerous symptom (priapism). If this happens, you should seek medical attention right away.
All Viagra generics are over the counter drugs that can be easily order from trusted online pharmacy. The <a href=”https://www.kamagraavenue.to/en/kamagra”>price of Kamagra</a> starts from 15 Eur. Sildenafil based medicine should not be used by anyone under the age of 18.
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