The past decade has seen an increasing interest in covalent organic frameworks (COFs) due to their enormous potential design space offered by the atomically precise spatial assembly of molecular organic building blocks. In January 2021, Alfa Chemistry announces the offering of COF linkers, to support research on organic frame materials and to meet the growing demand. A special website is built for customers to find COFs linkers as easily as possible.
COFs are now at the forefront of modern porous materials research. They represent an intriguing class of crystalline porous materials, where appropriately functionalized organic molecules are linked with an atomic level precision to give extended periodic structures. Such potentials can make COFs have unprecedented properties and applications.
“COFs stand out among various porous polymers by virtue of their crystallinity, diverse framework topologies and accessible pore systems. Comparing to other porous materials, COFs are superior for their stability,” says a senior scientist from Alfa Chemistry. “COFs are built from organic linkers via slightly reversible condensation reactions. A widely used linker core for COFs is phthalocyanine, either in its H‐form or complexed with a metal.”
It is very challenging to produce COFs that are simultaneously crystalline, stable, and functional as reversible bond formation is one of the prime prerequisites for the crystallization of COFs. However, with the advances in COF field, new strategies have surfaced, which can help to obtain both stable and crystalline COFs.
COF linkers are very important because their geometry and functionalization were proven to be an important determining factor for the crystallinity of the COF. Naphthalene‐2,6‐diyldiboronic acid (NPDA) and (ethyne‐1,2‐diylbis(4,1‐phenylene))diboronic acid (EDPDDA) as usd as COF linkers. At Alfa Chemistry, many more COF linkers are readily available, such as 4,4'-oxybisbenzenamine (CAS 101-80-4), Hexaethynylbenzene (CAS 100516-61-8), 1,3,5-Benzenetricarbonitrile (CAS 10365-94-3), Tetrakis(4-bromophenyl)methane (CAS 105309-59-9), bisamine diethynylbenzene (CAS 1141727-54-9), 2,3,6,7-tetramethoxy-9,9-dimethyl-9H-fluorene (CAS 1176891-87-4), 3,3'-Dimethylbiphenyl-4,4'-diamine (CAS 119-93-7), etc.
For more information about Alfa Chemistry's COF linker products, please visit

Author's Bio: 

Alfa Chemistry is a professional and reliable vendor of building blocks, reagents, catalysts and reference materials. With almost two decades of endeavors, it has now become a preferred choice of partner for many universities, research institutes as well as other organizations. Its broad range of product offerings cover heterocyclic organic compounds, boronic compounds, optoelectronic materials, organic building blocks, fluorinated building blocks, steroidal compounds, precious metal catalyst, material & chemicals, metal organics, nanomaterials, and more. In recent years, it closely follows the industry trends and has established a few sub-websites, which specifically focused on materials, catalysts, analytical reagents, functional polymers, etc.