Fairly recently, Alfa Chemistry announced the release of varieties of fluorescent probes, including ion probes, membrane potential probes, organelle fluorescent probes, and many other fluorescent probes, for research in multiple fields, such as clinical analysis, environmental monitoring, biological analysis, and life science.

As a consequence of excellent sensitivity and vast selectivity, fluorescent probes gain a competitive edge in terms of their straightforward preparation procedures and have been chosen as the most appropriate tools to detect chemical substances of interest in many research and industrial fields. Meanwhile, due to their optimum photophysical properties, fluorescent probes can also serve as essential research tools in bioimaging or other physiological studies for cellular level optimization.

“The most desirable fluorescent probes are bright, photo-stable, and excitable within the wavelength range of 450–750 nm. These properties realize single-molecule detection and research with extended observation time. Most importantly, they should be commercially available in a bioconjugatable form,” said the Marketing Chief of Alfa Chemistry.

Currently, Alfa Chemistry offers the following types of fluorescent probes, highly sensitive and efficient in response.

Ion Probes
As metal ions can greatly affect ecological stability, the detection of metal ions becomes a must. Ion probes have been widely used to detect Ca2+, Zn2+, Hg2+, Al3+, Cl-, ClO- and other special ions. A few of the ion probes provided by Alfa Chemistry are:
Dihydroethidium (CAS 38483-26-0), Fura-2AM (CAS 108964-32-5), Indo-1 (CAS 112926-02-0), BCECF,AM ester (CAS 117464-70-7), Fluo-3 AM (CAS 121714-22-5), etc.

Membrane Potential Probes
The membrane potential detection technology has attracted extensive attention. Recently, certain classical fluorescent dyes containing TMRM (tetramethyl rhodamine methyl ester), TMRE (tetramethyl rhodamine ethyl ester), Rhodamine 123 (Rh 123), and JC-1 cationic groups have been developed to synthesize the membrane potential probes. Alfa chemistry provides various membrane potential probes, just to name a few here: DiSC3(5) (CAS 53213-94-8), DiBAC4(5) (CAS 63560-89-4), RH 237 (CAS 83668-91-1), Di-4-ANEPPS (CAS 90134-00-2), DiOC2(3) (CAS 905-96-4), etc.

Organelle Fluorescent Probes
Organelle fluorescent probes, such as endoplasmic reticulum-targetable fluorescence probes, mitochondria-targetable fluorescent probes, and lysosome-targetable fluorescence probes, are widely applied according to the different cellular compartments of applications. Some of these chemicals are: DiR (CAS 100068-60-8), 4-Di-2-ASP (CAS 105802-46-8), CalceinAM (CAS 148504-34-1), Mito-TrackerGreen (CAS 201860-17-5), DiO (CAS 34215-57-1), etc.

In addition to the above-mentioned fluorescent probes, Alfa Chemistry also provides two-photon fluorescent probes, qPCR probes, as well as probes of diverse applications for extensive scientific research. Please visit https://photochem.alfa-chemistry.com/products/fluorescent-probes-4931.html to learn more.

Author's Bio: 

As a long-term partner for some of the leading companies and research institutes in the chemical industry, Alfa Chemistry has established a new product line centered on supplying a complete range of high-quality photochemistry-related products and services. Its ultimate goal is to help transform amazing photochemistry ideas into reality.