As a professional service provider in the field of Proteolysis Targeting Chimeric (PROTAC) technology, BOC Sciences offers a number of research and development outsourcing services. Recently, BOC Sciences announced that its PROTACs technology platform can provide E3 ubiquitin ligase activity assay services to assist drug development.

E3 ubiquitin ligase plays an important role in specifically recognizing target proteins and regulating the efficiency of ubiquitin reaction. The specificity of E3 protein substrates can be reprogrammed to treat diseases with effective and selective small molecular ligands targeting E3 ligases. The human genome encodes more than 600 kinds of E3 ubiquitin ligases, but only some of them can be recruited to degrade the target protein (POI), such as von Hippel-Lindau (VHL), cereblon (CRBN), inhibitors of apoptosis (IAPs), and mouse double minute 2 homolog (MDM2). E3 ubiquitin ligase activity affects the ubiquitin process, thus affecting the degradation of target proteins. Therefore, the determination of E3 ubiquitin ligase activity is of great significance in the research related to PROTAC technology.

BOC Sciences has a variety of E3 ubiquitin ligase activity testing platforms, covering both traditional and non-traditional technologies, including Tandem Ubiquitin Binding Entities (TUBEs)-based E3 Ubiquitin Ligase Activity Assay, Western Blot-based E3 Ubiquitin Ligase Activity Assay, etc.

In addition to the above services, BOC Sciences is dedicated to the design of ligands and screening of E3 ligases of interest. And according to specific requirements, it offers clients a comprehensive series of ligand products as well as customized ligand design and screening services to accelerate the development of PROTACs.

About BOC Sciences
BOC Sciences has been closely involved with drug discovery, chemistry and life science by supplying a comprehensive collection of chemicals to researchers, such as inhibitors, metabolites, impurities and natural compounds. Meanwhile, it also provides a wide range of services through all stages of drug R&D to support the pharmaceutical industry, like custom synthesis of chemicals, isotope labeling, formulation service, antibody drug conjugates, chiral synthesis and resolution.

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About BOC Sciences
BOC Sciences has been closely involved with drug discovery, chemistry and life science by supplying a comprehensive collection of chemicals to researchers, such as inhibitors, metabolites, impurities and natural compounds. Meanwhile, it also provides a wide range of services through all stages of drug R&D to support the pharmaceutical industry, like custom synthesis of chemicals, isotope labeling, formulation service, antibody drug conjugates, chiral synthesis and resolution.