CD Formulation Stresses the Importance of Increased Bioavailability Excipients in Drug Formulation

Specializing in drug formulation, the highly specialized CRO service provider CD Formulation has accumulated abundant experience in the custom synthesis of increased bioavailability excipients. To meet the requirements of different drug research projects, excipients can be tailor-made in varied specifications and volumes.

Recently, adding increased bioavailability excipients in drug formulations has gained widespread attention because they can alter the pharmacokinetics of drugs, ultimately resulting in improved bioavailability.

Although new advances in drug discovery, design and development have given rise to an increasing number of drug candidates, many of them failed to enter the market because of their low bioavailability. “How to improve the solubility, bio-availability and therapeutic performance of pharmaceutical ingredients has become the top conce
for the majority of drug developers,” said the Marketing Manager of CD Formulation.

To overcome such challenges, traditionally several techniques have been put into trial, including solid dispersion, micronization, solvent evaporation, ordered mixing, solvent deposition inclusion, and steam-assisted granulation.

With the addition of increased bioavailability excipients, some long-standing issues in this regard can be effectively resolved. Just to name a few: first, the solubility of APIs in the dosage form will be improved; second, the dissolved state of the API in the gastrointestinal tract can be maintained for a longer time; third, increased bioavailability excipients can even co-work with the digestion and absorption of physiological lipids in the body to promote the absorption of drugs.

At present, three major types of Increased Bioavailability Excipients can help improve bioavailability.

Carbohydrate-based parenteral excipients, such as trehalose, sucrose, mannitol, sorbitol, and maltose.

Polymer excipients, such as povidone and hydroxypropyl succinate.

Surface Active Agent - Surfactants, for instance, polyethylene glycol glycerol can be used to prepare lipid-based formulations that significantly improve solubility and thus oral bioavailability through various self-emulsifying systems.

“As a reliable partner in the drug formulation field, we are fully devoted to solving problems conce
ing solubility, bioavailability, and drug absorption. Our custom synthesis service for increased bioavailability excipients is worth a try in every way.”

Please visit https://www.formulationbio.com/products/increased-bioavailability-excipients.html to learn more.