Karela (Momordica Charantia) herb is very useful in Diabetes Mellitus

Bitter Melon, also known as Karela, Momordica Charantia or Bitter Gourd is a herb that helps regulate blood sugar levels and keeps body functions operating normally. It contains Gurmarin, a polypeptide considered to be similar to bovine insulin, which has been shown in experimental studies to achieve a positive sugar regulating effect by suppressing the neural response to sweet taste stimuli. Karela principle constituents are lectins, charantin and momordicine. The fruits have long been used in India as a folk remedy for diabetes mellitus.

Rich in iron, bitter melon has twice the beta carotene of broccoli, twice the calcium of spinach, twice the potassium of bananas, and contains vitamins C and B 1 to 3, phosphorus and good dietary fiber. It is believed to be good for the liver and has been proven by western scientists to contain insulin, act as an anti-tumor agent, and inhibit HIV-1 infectio

At least three diverse groups of components in bitter melon been have indicated to have hipoglicémicas actions (sugar of the blood that lower) or others of the potential advantage in mellitus of the diabetes. These include a mixture of saponins steroidal known like charantin, insulin-like peptides, and the alkaloids. It continues being non understandable that of these is most effective, or if work three together. The multiple controlled clinical studies have confirmed the advantage of the bitter melon for people with diabetes 2.

To date, close to 100 in vivo studies have demonstrated the blood sugar-lowering effect of this bitter fruit. The fruit has also shown the ability to enhance cells uptake of glucose, to promote insulin release, and to potentiate the effect of insulin. In other in vivo studies, bitter melon fruit and/or seed has been shown to reduce total cholesterol. In one study, elevated cholesterol and triglyceride levels in diabetic rats were returned to normal after 10 weeks of treatment.

Several in vivo studies have demonstrated the antitumorous activity of the entire plant of bitter melon. In one study, a water extract blocked the growth of rat prostate carcinoma; another study reported that a hot water extract of the entire plant inhibited the development of mammary tumors in mice. Numerous in vitro studies have also demonstrated the anticancerous and antileukemic activity of bitter melon against numerous cell lines, including liver cancer, human leukemia, melanoma, and solid sarcomas.

Bitter melon, like several of its isolated plant chemicals, also has been documented with in vitro antiviral activity against numerous viruses, including Epstein-Barr, herpes, and HIV viruses. In an in vivo study, a leaf extract increased resistance to viral infections and had an immunostimulant effect in humans and animals, increasing interferon production and natural killer cell activity.

In addition to these properties, leaf extracts of bitter melon have demonstrated broad-spectrum antimicrobial activity. Various extracts of the leaves have demonstrated in vitro antibacterial activities against E. coli, Staphylococcus, Pseudomonas, Salmonella, Streptobacillus, and Streptococcus; an extract of the entire plant was shown to have antiprotozoal activity against Entamoeba histolytica. The fruit and fruit juice have demonstrated the same type of antibacterial properties and, in another study, a fruit extract demonstrated activity against the stomach ulcer-causing bacteria Helicobacter pylori.

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