When Blood Cells Go Wild

For your body to function properly, it needs a steady supply of oxygenated blood that is supplied by red blood cells. These blood cells carry oxygen from the lungs to different parts of the body to give you energy and keep the skin healthy.

But if the bone marrow makes too many red blood cells, the blood thickens and trouble begins. This is called polycythemia vera – a blood disorder that causes many health problems.

“Polycythemia vera - also called primary polycythemia - occurs most often in older adults. It's rare in people younger than 20. Polycythemia vera usually develops very slowly. You may have it for years without noticing any signs or symptoms. Often, polycythemia vera is found during a blood test done for some other reason,” said the Mayo Clinic.

In the early stages, the disease has no symptoms. As it progresses, the patient may have headaches, dizziness, shortness of breath, difficulty breathing especially when lying down, chest pain, numbness and fatigue.

No one knows why people get polycythemia vera but it appears to be caused by a mutation in red blood cell production. The mutation is acquired but how this happens is a mystery. What we know if that the disease is common in older people, it affects more men than women and it appears to run in families.

“The problem with blood cell production associated with polycythemia vera is caused by a change, or mutation, to DNA in a single cell in your bone marrow. In polycythemia vera, researchers have found this mutation to be a change in a protein switch that tells the cells to grow. Specifically it's a mutation in the protei
JAK2 (the JAK2 V617F mutation),” explained the Mayo Clinic.

“More than 90 percent of patients with polycythemia vera, and about half of patients with other myeloproliferative disorders, have this mutation. Doctors and researchers don't understand the full role of this mutation and its implications for treating the disease,” it added.

But don't feel so bad if you have this condition since you can live with the disease in the absence of complications like a stroke, heart attack, an enlarged spleen and skin problems.

“Polycythemia vera causes your blood to be thicker than normal, which can slow the rate of blood flow through your veins and arteries. Increased blood thickness and decreased blood flow, as well as abnormalities in your platelets, increase your risk of blood clots. Blood clots can cause a stroke, a heart attack, or blockage of an artery in your lungs (pulmonary embolism) or in a vein deep within a muscle (deep vein thrombosis),” warned the Mayo Clinic.

Treatment is aimed at keeping the red blood cell level within a tolerable range. This can be done with the use of drugs, phlebotomy (removing blood) or low-dose aspirin to decrease clotting and reduce the chance of a stroke or heart attack.

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