Regaine is the first medication in the history approved by FDA for treating male pattern hair loss. By now it has been approved and is available as a cure for male pattern baldness worldwide. Its main active ingredient is minoxidil, a vasodilator that was originally used in the form of an oral drug Loniten to treat high blood pressure. Minoxidil is a hair-growth stimulant but its exact working is still not known. As Loniten has long come off patent, generic minoxidil is widely available in drugstores at a very reasonable price and in most countries it does not require a doctor’s prescription.

Both Regaine and generic minoxidil solutions come in concentrations of 2% for women and 5% for men but many experimental, generic products use concentrations of up to 20%. Minoxidil is frequently blamed for causing various negative side effects. Since it has become the most commonly-used drug for treating baldness, its side effects are very well documented and they happen to be often exaggerated. In less than one percent of patients they include an irregular or fast heart beat, very low blood pressure, blurred vision, swelling face and ankles, numbness in the hands, etc. These symptoms are directly related to minoxidil being a vasodilator. In addition, minoxidil can cause increased hair growth on the face and other parts of the body. This is due to its ability to stimulate hair growth. But some side effects that minoxidil is often blamed for are not caused by minoxidil itself.

They include inflammation, itchiness and redness of the scalp, dandruff and allergic reactions. These side effects can be attributed to the vehicles used in the solution, such as propylene glycol and isopropyl alcohol (propanol). Many hair loss sufferers have discontinued their minoxidil treatment because of scalp problems, although minoxidil rarely causes such negative reactions.
Furthermore, many generic, hair loss products contain supplementary ingredients that are supposed to enhance their overall efficacy, such as azelaic acid, retinoic acid, herbal extracts, etc. These substances, especially the herbal extracts, are known to be allergenic to many people.

It is advisable to try several different minoxidil-based products, for instance, those that do not contain propylene glycol, in order to test their tolerability for your scalp. A more expensive product, e.g. the original formulation - Regaine solution - is not necessarily a better option than a less expensive generic mixture. However, Regaine foam, though quite expensive, is typically very well tolerated. Anti-dandruff shampoos, e.g. Nizoral, can, in the majority of patients, be employed successfully to treat scalp inflammations, itchiness and dandruff caused by the use of minoxidil-based topical products.

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