Resveratrol is a polyphenolic compound, also known as ninhydrin, a chemopreventive agent for tumors, and a chemopreventive agent for reducing platelet aggregation, preventing and treating atherosclerosis, cardiovascular and cerebrovascular diseases. From peanuts [1], grapes (red wine), Polygonum cuspidatum, mulberry and other plants.

In 2014, scientists analyzed the levels of resveratrol in humans and the total mortality caused by various chronic diseases. It was found that dietary intake of resveratrol was not significantly associated with longevity, inflammation, cancer and cardiovascular health. Sex. Therefore, on the whole, there is not enough evidence to suggest that resveratrol is good for the human body. "At this stage, the scientific community still lacks sufficient understanding of resveratrol, and it cannot guarantee that it is beneficial or harmful.
Resveratrol is chemically known as (E)-3,5,4-trihydroxystilbene. It is a non-flavonoid polyphenol compound with a molecular formula of C14H12O3 and a relative molecular mass of 228.25. It is a white needle crystal and is easily soluble in organic solvents such as ether, chloroform, methanol, ethanol, acetone, acetic acid and ethyl ester at a wavelength of 365 nm. It can produce fluorescence under ultraviolet light and can react with ferric chloride-potassium ferricyanide.
Resveratrol is odorless, white crystals (methanol); insoluble in water, soluble in organic solvents such as ethanol and acetone. The temperature of 253-255 ° C, 261 ° C is sublimation.

Stability

It can produce fluorescence under ultraviolet light irradiation. When the pH is >10, the stability is poor. When the ferric chloride-potassium ferricyanide solution is blue, the alkaline solution such as ammonia water is red. Resveratrol is unstable to light, and the Microherb stability test shows that the ethanol solution of high-purity resveratrol can only be stable for several days in the dark. Therefore, it is recommended to use the reference solution for resveratrol content analysis. The sample solution is used with the solution.

Isomer

Resveratrol exists in free form and glycosidic form under natural conditions. The chemical structures of resveratrol and its glycosides also exist in cis and trans isomers, namely cis resveratrol ( cis-Res), trans-Res and trans-resveratrol glycosides (cis-PD), trans-resveratrol glycosides (trans-PD). The latter two forms resveratrol under the action of glycosidase in the intestine. Resveratrol in plants mainly exists in trans form. Studies have shown that the trans isomer is more physiologically active than the cis isomer.

Plant source

Resveratrol was first discovered in 1939. It was first discovered in grapes in the 1970s. Later, it was found that plants such as Polygonum cuspidatum, peanuts, and mulberry also contained this ingredient. Natural resveratrol is a natural active ingredient that can be distributed and biosynthesized in plants (such as Chinese medicinal material Polygonum cuspidatum) in free (cis, trans) and glycosidic (cis, trans) forms. And all have antioxidant effects, wherein the trans isomer is more biologically active than cis and is an important phytoalexin in grapes.People have conducted extensive research on their natural resources, and found resveratrol in at least 72 families of 31 families and 31 genera, such as: grape genus, snake genus, leguminous genus, Cassia, genus, cucurbitaceae of the family Liliaceae, genus of the genus Myrtaceae, genus of the genus Polygonaceae. Many plants containing resveratrol are common medicinal plants, such as cassia, gourd, knotweed, etc., some are food, such as: grapes, grape skin, the highest content of resveratrol, up to 50 ~ 100mg /kg.

Resveratrol was first discovered in commercial wines in 1992. Numerous studies have shown that resveratrol is the most important ingredient in wines, especially red wines. However, not all red wines have this ingredient, which is undetectable in blended and inferior wines. Because resveratrol is a phytoalexin produced by the vine in order to resist mold invasion, it remains in the grape skin after it is produced. Only red wine brewed in the traditional way, the resveratrol in the grape skin will be dissolved by the gradually produced alcohol during the brewing process. Some scholars believe that trans-resveratrol is an important component of red wine against atherosclerosis and coronary heart disease.

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