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Articles from Thomas Schmitt | Selfgrowth.com
- Gold Nanoparticles in Medicine: A Tiny Marvel with Big Potential - by Submitted on Nov 27, 2023 from Thomas SchmittWith the continuous development of nanotechnology, gold nanoparticles are widely used in the field of medicine. Gold nanoparticles not only have good controllability, biocompatibility, and biosorption, but also have a high degree of stability, and can achieve specific biometrics and functions ...
Views: 295 - Staphylococcus Aureus Enterotoxin B Detection Method - by Submitted on Nov 27, 2023 from Thomas SchmittStaphylococcus aureus (S. aureus) is an important class of food-borne pathogens that cause food contamination and food poisoning, and is also a symbiont of human skin and mucous membranes. Studies have found that about 20%~30 % of healthy individuals carry Staphylococcus aureus. Animal foods are ...
Views: 237 - Research on Capsular Polysaccharide Protein Conjugate Vaccine of Streptococcus Pneumoniae - by Submitted on Nov 27, 2023 from Thomas SchmittStreptococcus pneumoniae is a class of Gram-positive pathogenic bacteria that was first isolated in 1881. The chemical composition of the mucus layer on the surface of Streptococcus pneumoniae is a polysaccharide capsule, which is the main pathogenic substance of Streptococcus pneumoniae and has ...
Views: 286 - What is Nano Dressing? - by Submitted on Oct 30, 2023 from Thomas SchmittNanotechnology has not only received attention and applications in the field of drug delivery, but also has achieved many successes in the field of tissue engineering. Nano dressings can be defined as dressings in which nanomaterials are the matrix. The birth of nano dressings has brought new ...
Views: 319 - What Are PMMA Micro- and Nanoparticles? - by Submitted on Oct 30, 2023 from Thomas SchmittPoly(methyl methacrylate) (PMMA) micro- and nanoparticles are highly spherical, optically clear, and can be dissolved with solvents. These PMMA particles are hydrophilic, transparent, amorphous and colorless thermoplastics that are featured with excellent UV resistance. What is PMMA used ...
Views: 300 - Type 1 Diabetes Autoantibody Research - by Submitted on Oct 30, 2023 from Thomas SchmittType 1 diabetes (T1DM) is an autoimmune disease caused by the destruction of beta cells first, leading to the destruction of related pancreatic islet function. In patients with this disease, generally their humoral immunity and cellular immunity cannot work normally. Humoral immunity is ...
Views: 302 - Type 1 Diabetes Autoantibody Diagnosis - by Submitted on Oct 30, 2023 from Thomas SchmittType 1 diabetes (T1DM) is an autoimmune disease caused by the destruction of beta cells, leading to the destruction of related pancreatic islet functions. In patients with this disease, both humoral and cellular immunity generally do not work properly. Among them, humoral immunity is mainly ...
Views: 253 - Natural Nanocarriers for Delivery Protein Drug - by Submitted on Sep 20, 2023 from Thomas SchmittProtein accounts for 18-20% of the total mass of the human body and is the main carrier of human life activity. Protein has a range of complex functions in the organism, and many human diseases are closely related to the functional regulation of protein. For example, Parkinson’s disease (PD). It ...
Views: 275 - Mastering Colloidal Gold Handling, Storage, and Applications - by Submitted on Sep 20, 2023 from Thomas SchmittColloidal gold is a certain-size gold particle synthesized by gold ion reduction and polymerization of chloroauric acid (HAuCl4) under the action of reducing agents such as white phosphorus, ascorbic acid, sodium citrate, tannic acid, and so on. Due to electrostatic action, gold particles repel ...
Views: 280 - The Relationship Between Gangliosides and Nervous System Development - by Submitted on Sep 20, 2023 from Thomas SchmittGangliosides (GA) are a class of glycosphingolipids (GSLs) containing sialic acid, which are widely distributed in tissues and body fluids, and are most abundant in the nervous system, where their expression accounts for 10 % ~ 12% of the total lipids in nerve cell membranes. Gangliosides ...
Views: 282 - What is the role of TRIM11 in tumors? - by Submitted on Sep 20, 2023 from Thomas SchmittTripartite-motif Protein Family (TRIM) TRIM is composed of more than 80 proteins with E3 ubiquitin ligase activity. According to the different structures of TRIM proteins, they are divided into 11 subfamilies (C-I-C-Ⅺ), of which the C-Ⅳ subfamily has the most members, including 33 TRIMs ...
Views: 274 - What Is Polylactide? - by Submitted on Aug 18, 2023 from Thomas SchmittPolylactide (PLA), also the polylactic acid, is the biodegradable hydrolyzable aliphatic semicrystalline polyester that can be produced through the direct condensation reaction of its monomer, lactic acid, as the oligomer, and also by a ring-opening polymerization of the cyclic lactide ...
Views: 324 - Advances in Research on Iron Oxide Nanoparticles to Amplify Tumor Imaging Signals - by Submitted on Aug 18, 2023 from Thomas SchmittIron oxide nanoparticles have high stability, good dispersion, simple preparation and good biocompatibility. They have shown a wide range of application prospects in the fields of sensor detection, disease diagnosis, gene therapy vectors, and targeted drug delivery. Recently, a research team has ...
Views: 281 - Can PIVKA-II be Used in Liver Cell Cancer Research? - by Submitted on Aug 18, 2023 from Thomas SchmittHepatocellular cancer (HCC) is a clinically common malignant tumor of the digestive tract, which is seriously harmful to human health, and according to the survey, liver cancer accounts for the fifth largest incidence of tumors worldwide and the third mortality rate. At present, liver cancer in ...
Views: 303 - Is Aspartame Safe? - by Submitted on Aug 18, 2023 from Thomas SchmittAspartame is an artificial dipeptide sweetener, which is synthesized from L-phenylalanine and aspartic acid, and its scientific name is L-aspartic acid-L-phenylalanine methyl ester. It is a white crystalline powder that can be hydrolyzed into aspartic acid and phenylalanine in the body acid, ...
Views: 307 - What is a Micro Needle Array Based on Nanomaterials? - by Submitted on Jul 16, 2023 from Thomas SchmittMicro needle (MN) is a micro needle-shaped structure, the length of 100 ~ 1000μm, the bottom diameter of several hundred micrometers, the tip diameter is less than a few dozen micrometer, usually in the form of micro- needle array sticker, can penetrate the skin surface cortex to form ...
Views: 283 - The Potential Toxicological Effects of Microplastics (Polystyrene Particles) On Human - by Submitted on Jul 16, 2023 from Thomas SchmittMicroplastics (such as polystyrene particles), which are small plastic particles, films, fragments, pellets, and textile fibers, are the main carriers that cause environmental pollution. Microplastics, whose particle sizes range from a few microns to a few millimeters, are inhomogeneous plastic ...
Views: 272 - An Overview of Research on Human Metapneumovirus Infection - by Submitted on Jul 16, 2023 from Thomas SchmittRespiratory tract infection is an important cause of human morbidity and death worldwide and one of the main causes of death in children under 5 years old. Since 2001, researchers in the Netherlands reported a new virus related to respiratory tract infections in humans, especially infants – ...
Views: 286 - Immunological Study on Human Metapneumovirus - by Submitted on Jul 16, 2023 from Thomas SchmittSince Dutch researchers discovered human metapneumovirus (hMPV) in 2001, hMPV and its subtypes have been detected in many countries. hMPV is a respiratory pathogenic virus, which belongs to paramyxovirus, and can express a variety of proteins. Among them, the G, F, and M2 gene proteins are the ...
Views: 302 - A Short Biography of Carbon Dots - by Submitted on Jun 28, 2023 from Thomas SchmittCarbon dots (CDs) are a new type of zero-dimensional fluorescent nanomaterials with a size of less than 10 nm, which are composed of a graphitized sp2 carbon core and a shell containing abundant groups such as amino groups, ether groups, carbonyl groups, and hydroxyl groups on the surface, has ...
Views: 283 - How Do Silver Nanoparticles Kill Bacteria? - by Submitted on Jun 28, 2023 from Thomas SchmittSilver nanoparticles (AgNPs) are particles composed of silver atoms, and their particle sizes are usually in the range of 100 nm. Due to their unique physical and chemical properties, silver nanoparticles have been widely used in medical, food, health, consumer, and industrial fields. These ...
Views: 283 - What is Candida Albicans Infection? - by Submitted on Jun 28, 2023 from Thomas SchmittIn recent years, with the changes in human environment and diseases, the incidence of fungal infections has been increasing year by year. Candida albicans is one of the important pathogens causing fungal infections. In addition, it is also an important food-borne pathogen. Therefore, it is of ...
Views: 293 - What is FGL2? - by Submitted on Jun 28, 2023 from Thomas SchmittInflammation is a series of complex response events produced by the host system to pathogen infection and various tissue injuries. When the inflammatory response continues, it enters the stage of “uncontrollable inflammation”, which plays an important role in the occurrence and development of ...
Views: 278 - Research Progress of Pectin and Its Medical Application - by Submitted on May 28, 2023 from Thomas SchmittPectin is a hydrophilic vegetable gum. Widely present in the fruits, roots, stems and leaves of higher plants, it is a component of the cell wall. The pectin ontent of different plants or different parts of the same plant varies greatly. So far, only a few plants with high pectin content have ...
Views: 296 - How Do You Test Staphylococcus aureus? - by Submitted on May 28, 2023 from Thomas SchmittStaphylococcus aureus is an important pathogen causing suppurative infection in humans and animals, and it is also one of the common pathogens causing human food poisoning. Staphylococcus aureus is widely distributed in nature, such as air, soil, water, and other environments. This bacteria is ...
Views: 276 - Calprotectin in Inflammatory Diseases - by Submitted on May 28, 2023 from Thomas SchmittInflammation is an important defense response of the body that can control and clear various endogenous or exogenous damaging factors acting on the body, and also has a role in repairing damage. However, excessive or persistent inflammation can also cause damage to tissues and organs. ...
Views: 294 - What is Antibody-Dependent Enhancement - by Submitted on May 28, 2023 from Thomas SchmittAfter the host is infected by the virus, the immune system can generate a corresponding immune response. Antibodies specific to viral surface proteins produced at this time can often prevent the virus from adhering to the surface of host cells, making it incapable of infecting cells. However, in ...
Views: 274 - Carrageenans as a Versatile Tool in Drug Delivery - by Submitted on May 08, 2023 from Thomas SchmittDrug delivery is the process of administering pharmaceutical substances to targeted areas in the body. It plays a vital role in the effective treatment of various diseases. However, drug delivery is often challenged by the body’s natural defenses, such as the gastrointestinal tract and the ...
Views: 323 - What Are Polyethylenimine Magnetic Particles? - by Submitted on May 08, 2023 from Thomas SchmittPolyethylenimine (PEI) is a cationic polymer that contains repeating units composed of an amine group and a CH2CH2 spacer. Notably, PEI is an organic polymer that has the highest positive charge density potential as every third atom of this polymer is a protonable amino nitrogen. Two forms of ...
Views: 308 - Antibody-Immunoglobulin - by Submitted on May 08, 2023 from Thomas SchmittAntibody, also called Immunoglobulin, is a large Y globulin secreted by Effector B cell which is used in identifying and neutralizing the outsiders like bacterial and virus. Antibody is only found in blood ,body fluid and cytomembrane’s surface of Vertebrate. In addition, antiboy can identify ...
Views: 295 - What are AMOTs? - by Submitted on May 08, 2023 from Thomas SchmittAMOT family, also known as the Motin family, has three members: angiomotin (AMOT), angiomotin-like protein 1 (AMOTL1), and angiomotin-like protein 2 (AMOTL2). There are two shear isomers of AMOT, AMOT-P130 and AMOT-P80. AMOT was first discovered and named in 2001. Existing studies have shown ...
Views: 334 - What Are Phosphate Magnetic Particles? - by Submitted on Apr 03, 2023 from Thomas SchmittPhosphonates or phosphonic acids are organic compounds containing C–PO(OH)2 or C–PO(OR)2 groups (where R = alkyl, aryl). Most phosphonates are highly water-soluble, while phosphonic acids are only sparingly soluble. Phosphonates are not volatile and are poorly soluble in organic solvents. ...
Views: 313 - A Review of Proteolytic Targeting Chimeras - by Submitted on Apr 03, 2023 from Thomas SchmittThe concept of proteolytic targeting chimera (PROTAC) was first proposed by Crews and Deshaies laboratory in 2001, the team successfully achieved the degradation of methionyl aminopeptidase 2 (MetAp-2) by PROTAC method. Since then, PROTACs targeting androgen receptor (AR) and estrogen receptor ...
Views: 324 - Study on Partial Glycoprotein of Feline Herpesvirus Type 1 - by Submitted on Apr 03, 2023 from Thomas SchmittFeline herpesvirus type 1 (FHV-1) can cause acute and highly contagious infectious diseases in cats, namely feline infectious rhinotracheitis. In 1958, FHV-1 was isolated and identified for the first time from kittens suffering from respiratory diseases in the United States by Crandell et al. ...
Views: 259 - Influenza A: Unraveling the Mystery of H1N1 and H3N2 - by Submitted on Apr 03, 2023 from Thomas SchmittInfluenza A viruses, the culprits of respiratory illness in humans, are a complex and multifaceted group of viruses. Among the numerous subtypes of Influenza A, H1N1 and H3N2 with a notorious history of causing seasonal epidemics and pandemics, demand special attention. Influenza A H1N1, also ...
Views: 292 - A Non-invasive Test for Detecting and Locating Cancer Cells - by Submitted on Mar 03, 2023 from Thomas SchmittWhen diagnosing cancer, most of the tests used by doctors (such as mammography, colonoscopy, and CT scans) are based on imaging. Engineers at the Massachusetts Institute of Technology have now created new diagnostic nanoparticles that can be used to monitor tumor recurrence after treatment or to ...
Views: 293 - Gene Carrier Based on Nanomaterials - by Submitted on Mar 03, 2023 from Thomas SchmittGene therapy refers to the introduction of normal foreign genes into target cells to compensate or correct diseases caused by gene defects or abnormalities, so as to achieve the purpose of treatment. Naked DNA usually requires physical methods to enter tissues or cells, and DNA is easily ...
Views: 304 - Detection of Impurities Related to Biopharmaceutical Processes - by Submitted on Mar 03, 2023 from Thomas SchmittBiopharmaceutical impurities can be divided into two categories: extraneous contaminants and product-related impurities. Extraneous contaminants include microbial contamination, pyrogens, cellular components, components in culture media, substances from various steps in the production process, ...
Views: 256 - Transglutaminases in Medical Research - by Submitted on Mar 03, 2023 from Thomas SchmittTransglutaminase (TGase) is an enzyme that catalyzes the acyl transfer reaction. It uses the C-carboxamide group of the glutamine residue in the peptide bond as the acyl donor, and the E-amino group of the lysyl residue in the polypeptide chain as the acyl acceptor, forming intramolecular and ...
Views: 298 - Introduction of Chitosan as Nano-drug Delivery Carrier - by Submitted on Feb 01, 2023 from Thomas SchmittChitin is the second largest natural polymer after cellulose, and it exists widely in nature, such as shells of crustaceans such as shrimps, crabs, insects, and cell walls of fungi. Although chitin has good biocompatibility and biodegradability, its poor solubility limits its practicality in the ...
Views: 405 - What Are Melamine Resin Particles? - by Submitted on Feb 01, 2023 from Thomas SchmittMelamine (1, 3, 5-triamino-2, 4, 6-triazine) resin, or melamine formaldehyde (MF) is one of the hardest and stiffest thermosetting polymers, which provides good properties and performance. It is an amino resin and has various material advantages, such as transparency, better hardness, thermal ...
Views: 380 - Cancer Target: Mesothelin - by Submitted on Feb 01, 2023 from Thomas SchmittMesothelin is a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein. Its biological function has not yet been clarified, but due to its limited distribution in normal tissues and high expression in some tumor tissues, it is expected to be used in tumor-specific treatment. In ...
Views: 328 - Breakthrough Ideas for Parkinson’s Disease Treatment - by Submitted on Feb 01, 2023 from Thomas SchmittParkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by bilateral motor (eg, bradykinesia, resting tremor, postural instability, rigidity) and nonmotor (eg, memory loss, depression) disability. About 10 million people worldwide suffer from Parkinson’s disease. ...
Views: 280 - Gene Structure and Function of Porcine Pseudorabies Virus - by Submitted on Dec 27, 2022 from Thomas SchmittPorcine pseudorabies (PR) is an acute infectious disease of pigs caused by porcine pseudorabies virus (PRV). PRV belongs to the herpesviridae family, the alphaherpesviridae subfamily, and the genus porcine herpesvirus, which is a linear DNA virus. PRV can cause vomiting, high fever and ...
Views: 303 - Research Status of Virus Vaccines - by Submitted on Dec 27, 2022 from Thomas SchmittSince the discovery of cowpox inoculation to prevent smallpox in the 18th century, vaccines have become an important means for human beings to resist pathogen infection and prevent the occurrence of diseases. Although immunization has eliminated or controlled the spread and pathogenic hazards of ...
Views: 308 - Research Progress of PROTAC in the Treatment of Malignant Tumors - by Submitted on Dec 27, 2022 from Thomas SchmittMalignant tumors are a major global public health problem, the leading cause of death in developing countries and the second leading cause of death in developed countries. Traditional treatment methods such as surgical resection, radiotherapy and chemotherapy have serious side effects on the ...
Views: 291 - What Are Gold NanoCages? - by Submitted on Dec 27, 2022 from Thomas SchmittGold nanocages refer to the hollow gold nanostructures with porous walls that were developed by Sun and Xia and Chen et al. in the early 2000s. The hollow and porous structures are synthesized by the galvanic replacement between silver nanocubes and chloroauric acid in aqueous solution. By ...
Views: 337 - What Is Nucleic Acid Extraction? - by Submitted on Nov 29, 2022 from Thomas SchmittNucleic acid is the main material for storing, copying, and transmitting genetic information. Nucleic acid extraction is one of the most fundamental steps in molecular biology applications and is a prerequisite for many experiments. The quality of extracted nucleic acid will directly affect the ...
Views: 311 - Advantages of Liposomal in Drug Delivery - by Submitted on Nov 29, 2022 from Thomas SchmittLiposomes are ultra-micro spherical carrier preparations formed by lipid bilayers, and are typical representatives of nano-drug delivery systems. When amphiphilic molecules such as phospholipids are dispersed in the aqueous phase, the hydrophobic tails of the molecules gather together, and the ...
Views: 319 - The Return of Bird Flu - by Submitted on Nov 28, 2022 from Thomas SchmittAccording to data from the European Food Safety Authority, the European Centre for Disease Prevention and Control and the EU Avian Influenza Reference Laboratory, large-scale bird flu has occurred in Europe since June in 2022, affecting 37 European countries, from Norway to Sri Lanka. The Valbar ...
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