Self Improvement Site
On The Internet! Take the Self Improvement Tour
On The Internet! Take the Self Improvement Tour
Articles from Thomas Schmitt | Selfgrowth.com
- Research on Genetically Engineered Drug Host Cell Proteins - by Submitted on Feb 27, 2024 from Thomas SchmittGenetically engineered drugs are introduced into host cells such as Escherichia coli, yeast or mammalian cells through recombinant technology to construct engineering strains or cell strains, and then undergo specific expression, assembly, folding and post-translational modification processes to ...
Views: 394 - Breakthrough Ideas for Parkinson’s Disease Treatment - by Submitted on Feb 01, 2023 from Thomas SchmittParkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by bilateral motor (eg, bradykinesia, resting tremor, postural instability, rigidity) and nonmotor (eg, memory loss, depression) disability. About 10 million people worldwide suffer from Parkinson’s disease. ...
Views: 393 - How Do You Test Staphylococcus aureus? - by Submitted on May 28, 2023 from Thomas SchmittStaphylococcus aureus is an important pathogen causing suppurative infection in humans and animals, and it is also one of the common pathogens causing human food poisoning. Staphylococcus aureus is widely distributed in nature, such as air, soil, water, and other environments. This bacteria is ...
Views: 393 - Advances in Research on Iron Oxide Nanoparticles to Amplify Tumor Imaging Signals - by Submitted on Aug 18, 2023 from Thomas SchmittIron oxide nanoparticles have high stability, good dispersion, simple preparation and good biocompatibility. They have shown a wide range of application prospects in the fields of sensor detection, disease diagnosis, gene therapy vectors, and targeted drug delivery. Recently, a research team has ...
Views: 392 - Influenza A: Unraveling the Mystery of H1N1 and H3N2 - by Submitted on Apr 03, 2023 from Thomas SchmittInfluenza A viruses, the culprits of respiratory illness in humans, are a complex and multifaceted group of viruses. Among the numerous subtypes of Influenza A, H1N1 and H3N2 with a notorious history of causing seasonal epidemics and pandemics, demand special attention. Influenza A H1N1, also ...
Views: 392 - New Research Shows That Shark Antibody-Like Protein Can Neutralize SARS-CoV-2 - by Submitted on Jan 05, 2022 from Thomas SchmittAccording to a new study published in December, small, unique antibody-like proteins called VNARs—from the shark’s immune system—can prevent the virus SARS-CoV-2 that causes COVID-19, its variants, and related coronaviruses from infecting human cells. This work is published in Nature ...
Views: 392 - Natural Nanocarriers for Delivery Protein Drug - by Submitted on Sep 20, 2023 from Thomas SchmittProtein accounts for 18-20% of the total mass of the human body and is the main carrier of human life activity. Protein has a range of complex functions in the organism, and many human diseases are closely related to the functional regulation of protein. For example, Parkinson’s disease (PD). It ...
Views: 388 - Micelle vs Liposome - by Submitted on Jan 23, 2024 from Thomas SchmittMicelles refer to molecularly ordered aggregates that begin to form in large quantities after the surfactant concentration reaches a certain value in an aqueous solution. In micelles, the hydrophobic groups of surfactant molecules aggregate to form the core of the micelle, and the hydrophilic ...
Views: 386 - Research Progress of PROTAC in the Treatment of Malignant Tumors - by Submitted on Dec 27, 2022 from Thomas SchmittMalignant tumors are a major global public health problem, the leading cause of death in developing countries and the second leading cause of death in developed countries. Traditional treatment methods such as surgical resection, radiotherapy and chemotherapy have serious side effects on the ...
Views: 385 - Lipid Nanomedicine Delivery In Vivo - by Submitted on Nov 27, 2023 from Thomas SchmittIn the past few decades, the advent of lipid-based nano-delivery systems has brought research in the field of nanomedicines to new heights. Nanocarriers can encapsulate different types of drug molecules and have the advantages of improving drug solubility, extending circulation, achieving ...
Views: 384 - What is Antibody-Dependent Enhancement - by Submitted on May 28, 2023 from Thomas SchmittAfter the host is infected by the virus, the immune system can generate a corresponding immune response. Antibodies specific to viral surface proteins produced at this time can often prevent the virus from adhering to the surface of host cells, making it incapable of infecting cells. However, in ...
Views: 384 - Food Allergen Sensitization Assessment Method-In Vivo Measurement - by Submitted on Apr 15, 2022 from Thomas SchmittFood allergy (food hypersensitivity) is an abnormal reaction of the body’s immune system caused by food. More precisely, it is an allergic reaction caused by allergens in food. Food allergy has become a global public health problem. According to reports, the incidence of allergic reactions in ...
Views: 383 - Research on Snake Venom Detection Methods - by Submitted on Apr 25, 2024 from Thomas SchmittSnake bites seriously threaten public health security in tropical and subtropical countries and regions. Due to the high mortality and disability rates caused by venomous snake bites, there are an estimated 1.8 to 2.7 million snake bites worldwide each year, with 81,000 to 138,000 related ...
Views: 382 - Testing for Respiratory Syncytial Virus - by Submitted on Apr 25, 2024 from Thomas SchmittRespiratory syncytial virus was isolated from the cold-like respiratory tract of chimpanzees in 1956. It is called respiratory syncytial virus because it causes the fusion of adjacent cells during cell culture and the formation of syncytial-like structures in the cells. According to different ...
Views: 382 - Adeno-Associated Virus Vector (AAV) Application Q&A - by Submitted on May 29, 2024 from Thomas SchmittAdeno-associated virus (AAV), as an important gene delivery and expression tool, has been widely used in the fields of scientific research and gene therapy in recent years. As a gene delivery system, AAV viral vectors have the advantages of good safety, low immunogenicity, the ability to infect ...
Views: 381 - Type 1 Diabetes Autoantibody Diagnosis - by Submitted on Oct 30, 2023 from Thomas SchmittType 1 diabetes (T1DM) is an autoimmune disease caused by the destruction of beta cells, leading to the destruction of related pancreatic islet functions. In patients with this disease, both humoral and cellular immunity generally do not work properly. Among them, humoral immunity is mainly ...
Views: 381 - Research Finds Antibodies Show Promise for Treatment of Hantavirus - by Submitted on May 24, 2022 from Thomas SchmittAn international team of researchers has discovered the first human antibody that effectively neutralizes two types of hantaviruses in animal models, according to a study published online in the journal Science Translational Medicine. Based on their preliminary results, the antibody appears to ...
Views: 379 - The Life Cycle of Epstein-Barr Virus - by Submitted on Jul 20, 2022 from Thomas SchmittEpstein-Barr Virus (EBV) is a large enveloped virus of double-stranded DNA among the eight known herpesviruses. After EBV infection of cells, it accumulates in the nucleus, and there are two life cycles, with alternating phases of latency and lysis. EBV infection is associated with a variety of ...
Views: 379 - What is the role of TRIM11 in tumors? - by Submitted on Sep 20, 2023 from Thomas SchmittTripartite-motif Protein Family (TRIM) TRIM is composed of more than 80 proteins with E3 ubiquitin ligase activity. According to the different structures of TRIM proteins, they are divided into 11 subfamilies (C-I-C-Ⅺ), of which the C-Ⅳ subfamily has the most members, including 33 TRIMs ...
Views: 379 - Application of Transfersomes and Ethosomes in Transdermal Drug Delivery - by Submitted on Jun 01, 2021 from Thomas Schmitthe transfersomes is a self-aggregating vesicle obtained by formulating and improving on the basis of liposomes, also known as flexible nano-liposomes (FNL). It is a lipid carrier obtained by adding surfactants (such as sodium cholate, polysorbate, spaan, sodium deoxycholate, etc.) to liposome ...
Views: 378 - The Potential Toxicological Effects of Microplastics (Polystyrene Particles) On Human - by Submitted on Jul 16, 2023 from Thomas SchmittMicroplastics (such as polystyrene particles), which are small plastic particles, films, fragments, pellets, and textile fibers, are the main carriers that cause environmental pollution. Microplastics, whose particle sizes range from a few microns to a few millimeters, are inhomogeneous plastic ...
Views: 376 - PLGA Nano Drug Carrier - by Submitted on Apr 25, 2024 from Thomas SchmittPoly(lactic-co-glycolic acid) (PLGA) is a functional polymer organic compound randomly polymerized by lactic acid (PLA) and glycolic acid (PGA). It has been approved by the U.S. Food and Drug Administration It is certified by the Food and Drug Administration (FDA) and is a copolymer material ...
Views: 374 - Effects of Glucagon-Like Peptide-1 Receptor Agonists on Diabetic Cardiomyopathy - by Submitted on Feb 27, 2024 from Thomas SchmittThe incidence and prevalence of diabetes are increasing year by year globally, and patients with diabetes are at increased risk of cardiovascular disease and heart failure. Diabetic cardiomyopathy (DCM) refers to the presence of abnormal myocardial structure and performance in the absence of ...
Views: 372 - The Mechanism of Adverse Immune Reactions of LNP-mRNA - by Submitted on May 29, 2024 from Thomas SchmittMany clinical trials of mRNA-based drugs or vaccines have failed to successfully pass Phase I or Phase II. The reasons behind this are various, including low efficacy of candidate drugs and lower-than-expected clinical risk/treatment benefit profiles. Preclinical safety assessments aim to ...
Views: 372 - Reprogramming of Lipid Metabolism in the Tumor Microenvironment - by Submitted on Jun 28, 2024 from Thomas SchmittReprogramming of lipid metabolism has become an important feature of cancer. In order to adapt to the hypoxic and nutrient-deficient microenvironment, tumor cells, in addition to increasing glucose uptake and aerobic glycolysis, also need to undergo lipid metabolism reprogramming to enhance ...
Views: 370 - Autoimmune Diseases and Their Detection - by Submitted on Jun 28, 2024 from Thomas SchmittAutoimmune diseases are diseases caused by an autoimmune response. The role of the human immune system is to protect the body from pathogenic microorganisms and cancer cells. When the immune system accidentally attacks your body instead of protecting it, it will cause damage or dysfunction of ...
Views: 368 - Application of Nanoparticles in CRISPR/Cas9 Gene Therapy - by Submitted on Jul 26, 2024 from Thomas SchmittAt present, genetic diseases are a large category of diseases that affect human health. So far, we can only treat a small part of them, and most of the treatment methods are "treating the symptoms but not the root cause". Therefore, gene therapy that can "cure the root cause" is highly ...
Views: 367 - The Role of Targeting p53 Signaling Pathway in Cancer Therapy - by Submitted on Dec 26, 2023 from Thomas SchmittAs a tumor suppressor, p53 is one of the most commonly mutated genes in human cancers. Due to its important role in tumor suppression, p53 has attracted great interest from researchers in drug development. As a transcription factor, p53 is directly or indirectly involved in regulating many ...
Views: 366 - How to Calculate the Volume, Mass, and Concentration of Gold Nanoparticle - by Submitted on Jul 28, 2024 from Thomas SchmittGold is a chemically stable metal with a molar mass of 196.96657 g/m and a density of 19.3 g/cm3. It is often used for decoration and money, but its properties change strangely when its size shrinks to the nanometer level. Gold nanoparticles have special physical and chemical properties ...
Views: 364 - What is Herpes Simplex Virus? - by Submitted on Jan 23, 2024 from Thomas SchmittHerpes simplex virus (HSV) belongs to the herpesvirus alpha subfamily and has a unique 4-layer structure. The core of HSV is a linear double-stranded DNA of about 152 000 bp, surrounded by an icosahedral capsid. The outer capsid is a membrane, which contains more than 20 important proteins that ...
Views: 363 - Polyacrylate Nanoparticles You Don’t Want to Miss - by Submitted on Jul 20, 2022 from Thomas SchmittWhat are polyacrylates nanoparticles? Polyacrylates are an important class of soft, tough and rubbery polymers, which are known for their high transparency, good impact toughness and elasticity. Polyacrylates and their copolymers are one of the polymeric nanoparticles (NPs). Polymeric ...
Views: 362 - The Role of Vitamin D in Anti-tumor I - by Submitted on Jul 26, 2024 from Thomas SchmittVitamin D is a fat-soluble vitamin that can be obtained from food. At the same time, cholesterol in the body can be oxidized to 7-deoxycholesterol, which is converted into vitamin D by ultraviolet radiation. It is the precursor of a powerful steroid hormone. It synthesizes biologically active ...
Views: 358 - Colored Polystyrene Particles in Developing Rapid and Affordable Point-of-Care Diagnostics - by Submitted on Apr 25, 2024 from Thomas SchmittPOCT (Point-of-Care Testing) refers to clinical and bedside testing conducted in close proximity to patients. It is often not performed by clinical laboratory personnel. POCT holds significant importance in disease prevention, etiology determination, prognosis, enhancing treatment outcomes, and ...
Views: 357 - Research on Metal Nanoclusters in the Field of Biomedicine - by Submitted on Mar 26, 2022 from Thomas SchmittDue to the excellent characteristics of metal nanoclusters, they have many applications in the field of biomedicine. Current research shows that metal nanoclusters have good application value in biosensors, nucleic acid and protein molecular detection. Application of Metal Nanoclusters in ...
Views: 357 - Staphylococcus Aureus Enterotoxin B Detection Method - by Submitted on Nov 27, 2023 from Thomas SchmittStaphylococcus aureus (S. aureus) is an important class of food-borne pathogens that cause food contamination and food poisoning, and is also a symbiont of human skin and mucous membranes. Studies have found that about 20%~30 % of healthy individuals carry Staphylococcus aureus. Animal foods are ...
Views: 356 - Study on Partial Glycoprotein of Feline Herpesvirus Type 1 - by Submitted on Apr 03, 2023 from Thomas SchmittFeline herpesvirus type 1 (FHV-1) can cause acute and highly contagious infectious diseases in cats, namely feline infectious rhinotracheitis. In 1958, FHV-1 was isolated and identified for the first time from kittens suffering from respiratory diseases in the United States by Crandell et al. ...
Views: 355 - Why the Desired Effect is not Achieved After Using AAV? - by Submitted on May 29, 2024 from Thomas SchmittAdeno-associated virus (AAV) is a small non-enveloped virus, belonging to the family Parvoviridae. It was first discovered in 1965 from contaminants of adenovirus isolates. It has an icosahedral structure on the outside and a diameter of about 26 nm. Its capsid protein is composed of It is ...
Views: 355 - Microfluidics Revolution: Polystyrene Particles Powering Miniaturized and Automated Immunoassays - by Submitted on May 29, 2024 from Thomas SchmittTraditional immunoassays based on the format of 96-well microtiter plates are widely used in analytical laboratories and have become increasingly automated with the introduction of robotics technology in recent years, thereby enhancing assay throughput. Most clinical analyzers essentially ...
Views: 353 - Detection of Impurities Related to Biopharmaceutical Processes - by Submitted on Mar 03, 2023 from Thomas SchmittBiopharmaceutical impurities can be divided into two categories: extraneous contaminants and product-related impurities. Extraneous contaminants include microbial contamination, pyrogens, cellular components, components in culture media, substances from various steps in the production process, ...
Views: 350 - Research Progress on the Immune Mechanism of Varicella-Zoster Virus - by Submitted on Jul 25, 2024 from Thomas SchmittVaricella-zoster virus (VZV) is a pathogen widely present in the global population, infecting more than 90% of the world’s population. VZV primary infection often occurs in childhood, which can cause chickenpox characterized by systemic vesicular eruptions, and after infection, it can remain ...
Views: 350 - A Brief Description of Porcine Reproductive and Respiratory Syndrome Virus - by Submitted on Nov 28, 2022 from Thomas SchmittPorcine Reproductive and Respiratory Syndrome Virus (PRRSV) belongs to the Arteriviridae family and belongs to the Arterivirus. PRRSV can be divided into type I (PRRSV type I) and type II (PRRSV type II). The main clinical symptoms are abortion, stillbirth and mummified fetus of pregnant sows, ...
Views: 344 - mRNA Nanocarriers - by Submitted on Jun 28, 2024 from Thomas SchmittAs an intermediate carrier, mRNA can transfer the genetic code in DNA to ribosomes for protein expression. It has great potential in vaccines, protein replacement therapy, and gene editing. Compared with traditional small molecule and protein drugs, mRNA-based therapies show some specific ...
Views: 342 - Reprogramming of Lipid Metabolism in the Tumor Microenvironment - by Submitted on Jul 25, 2024 from Thomas SchmittReprogramming of lipid metabolism has become an important feature of cancer. In order to adapt to the hypoxic and nutrient-deficient microenvironment, tumor cells, in addition to increasing glucose uptake and aerobic glycolysis, also need to undergo lipid metabolism reprogramming to enhance ...
Views: 335 - Research on Chimeric Antigen Receptor-Mediated Anti-Tumor Cell Therapy - by Submitted on Sep 25, 2024 from Thomas SchmittOver the past few decades, anti-tumor treatment has gradually evolved from traditional surgical resection, radiotherapy and chemotherapy to more precise molecularly targeted therapy and immunotherapy. These advances have improved the treatment of certain tumors to a certain extent. However, ...
Views: 333 - Techniques for Nanoparticle Size Characterization - by Submitted on Sep 25, 2024 from Thomas SchmittParticle size is an important detection index for nano-pharmaceutical preparations. All nano-pharmaceutical preparations must be tested for particle size and particle size distribution, including nano-emulsion, nano-crystals, nano-particles, and nanoplex. There are many particle size measuring ...
Views: 330 - Advantages and Disadvantages of Nucleic Acid Aptamers - by Submitted on Sep 25, 2024 from Thomas SchmittNucleic acid aptamers are single-stranded oligonucleotides with the ability to specifically bind to target molecules. Currently, nucleic acid aptamers are screened from large random nucleic acid libraries using SELEX technology. It can identify different types of target molecules such as ...
Views: 329 - Introduction of Animal Models in Development of Vaccines - by Submitted on Sep 25, 2024 from Thomas SchmittWhen Jenner discovered the smallpox virus in 1798, scientists realized that animal models could be a powerful tool for studying human infectious diseases. Animal models are commonly used to evaluate various immunological parameters: humoral and cell-mediated immunity, onset and duration of ...
Views: 329 - How Does COPD Affect the Lungs?-Animal Models Reveal the Truth - by Submitted on Nov 26, 2024 from Thomas SchmittWhat is COPD? Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammatory disease characterized by progressive airflow limitation. The main symptoms are cough, expectoration, and progressive worsening dyspnea. As of 2017, COPD has become the third-largest cause of death in ...
Views: 278 - Overview of Tumor Organoids - by Submitted on Nov 26, 2024 from Thomas SchmittMalignant tumors have become a major challenge in the field of global public health. How to continuously deepen the understanding of the occurrence and development of malignant tumors and continuously optimize the clinical diagnosis and treatment model of tumors is an important issue that needs ...
Views: 265 - As the Key Player in Sunscreen, Is Titanium Dioxide Safe or Not? - by Submitted on Nov 26, 2024 from Thomas SchmittOn February 18, 2020, the European Commission finally included respirable titanium dioxide as a suspected carcinogen (category 2) based on a 2017 proposal. So, what is titanium dioxide? How does it affect our lives? Titanium dioxide, also known as titania, has been active in our daily life ...
Views: 264