Anti-tumor Monoclonal Antibody (mAb)
The concept that cancer cells express certain potential target antigens paves the way for humanized antibodies as a therapeutic strategy for malignant tumors. Antibodies can interact with immune cells through the Fc domain of antibodies to target and destroy ... Views: 259
Drug delivery strategies (https://www.creative-biolabs.com/targeted-delivery/) have greatly facilitated the treatment and application of drugs. The rapid development of therapeutics is dependent on the continuous pursuit of advances in delivery technologies and strategies. Decades ago, small ... Views: 255
In the past few decades, both pharmaceutical companies and academia have spent much financial resources and energy to improve the practicability and accuracy of in vitro screening technology that can test the biological activity and physicochemical properties of compounds. However, the study of ... Views: 214
Nonsense mutations, which occur when a sense codon in a protein-coding sequence becomes a premature termination codon (PTC), are responsible for approximately 11% of human genetic diseases.
The translational process of mRNA to protein is carried out by tRNA, which recognizes the codon on mRNA ... Views: 166
Cornel University researchers recently made a breakthrough in the study of schizophrenia with human-derived cerebral organoids.
Schizophrenia is a chronic brain disorder of hitherto unknown exact etiology, with typical symptoms usually appearing in early adulthood and affecting approximately ... Views: 220
Immunotherapy, in addition to surgery, chemotherapy, and radiotherapy, has now become the fourth pillar of anticancer treatment, with T cell-based immunotherapy being a successful cancer treatment technique. T cells can be separated into two subpopulations based on the expression of T-cell ... Views: 293
The most commonly used murine monoclonal antibodies (mAbs) have played a crucial role in clinical diagnosis and treatment, which, however, have strong immunogenicity and can cause human anti-mouse antibody (HAMA) reactions in clinical applications, resulting in shorter antibody half-life (less ... Views: 351
The use of immune checkpoint inhibitors (ICIs) has become the most important achievement in oncology in the last decade. From a more holistic viewpoint, it is a powerful clinical strategy.
Cancer cells are transformed from normal cells, and through altering the tumor immune milieu, the ... Views: 343
The advent of the era of precision medicine takes monoclonal antibody (mAb) drugs that have high specificity and effectiveness to a hot spot in biological drug therapy.
In 1975, Georges Köhler and César Milstein successfully invented hybridoma technology, laying the foundation for monoclonal ... Views: 273
Researchers at the University of Helsinki have devised a new technique for returning human cells to a stem cell state that is faster and more reliable.
Pluripotent stem cells, which can differentiate into any cell in the body and can generate all tissues and organs, are the present focus of ... Views: 298
What are the effects of bacteriophages on the body's immune system?
Bacteriophages cannot infect eukaryotic cells, but more and more studies have shown that phages can regulate the immune response of mammals. Especially when the phage and the host bacteria ... Views: 237
As bacterial viruses, bacteriophages have been increasingly reported for their unique role in affecting bacterial diseases. Bacteriophages (https://phagenbio.creative-biolabs.com/) can directly control the composition and abundance of bacteria and indirectly affect the body's metabolism and ... Views: 264
Sweet sensations can be induced by both sucrose and artificial sweeteners, but animals and humans prefer the former. Even mice without taste receptors are able to distinguish between sucrose and sweets. Although the tongue is responsible for sweetness perception, the duodenum is crucial in ... Views: 610
For a long time, malaria is one of the most serious diseases threatening human health. According to the WHO, there were 229 million clinical cases of malaria worldwide in 2019, and more than 400,000 people died from this disease.
Although some countries have been confirmed by the WHO to ... Views: 251
Moderna launched a clinical study for an HIV mRNA vaccine in August 2021, on 56 HIV-negative people aged 18 to 50.
AIDS is a highly contagious disease. In 2020, the United Nations estimates that 37.7 million people would be living with HIV around the world. However, there is currently no ... Views: 296
SARS-CoV-2 (https://www.antibody-creativebiolabs.com/search.aspx?key=sars-cov-2&ty=product) swept the world in 2020, leading to blockades, social distancing, and huge economic losses. In addition, COVID-19 also triggered vaccine, treatment, and diagnostics competition, achieving the approval of ... Views: 582
In the emergency response to the COVID-19 epidemic, the first vaccines to be released are all based on mRNA technology. Recently, the "double mutation" mutant virus appeared in India, and mRNA vaccine has once again been highlighted due to its short research cycle.
Only a year ago, mRNA was ... Views: 195
Scientists have created a vaccine for experimental use that protects animals from both seasonal and pandemic variants of the influenza virus. Clinical trials of the vaccine are now under development. Next-generation vaccinations for the flu have the potential to replace seasonal choices if they ... Views: 229
It has been 35 years since the FDA approved the first monoclonal antibody in 1986. Antibody-based drugs account for nearly one-fifth of new FDA drug approvals each year.
In this time, antibody engineering (https://www.creative-biolabs.com/engineering-services.html) has changed dramatically. ... Views: 242
On August 12, 2021, data on the efficiency of real-world vaccine protection in the United Kingdom was published in the New England Journal of Medicine (NEJM).
Since the global outbreak of the COVID-19 epidemic in early 2020, various mutant strains have continued to emerge, including Alpha ... Views: 257
A huge population consume large amounts of ready-to-eat foods such as bread, biscuits, and various snacks every day, which have been highly or overly heat-processed. During the processing, the chemical structure of the food is changed, thereby prolonging their shelf life, palatability, and ... Views: 205
A team led by medical researchers at Case Western Reserve University has developed a potential treatment for Perizois-metzbach's disease (PMD). It is a fatal neurological disease caused by genetic mutations that prevent the body from producing myelin, which is a protective insulator around nerve ... Views: 209
The haze of the COVID-19 epidemic still hangs over human society and has yet to subside. As the northern hemisphere enters the cold season and a new mutant strain of Omicron emerges, a new wave of neo-crown epidemics seems to be emerging.
Since the approval of the first vaccine in early 2020, ... Views: 316
The development of new cancer therapy is based on the discovery of new characteristics and weaknesses of cancer cells. A group of Danish researchers found another characteristic of cancer cells through experiments on cancer cell membranes, that is, cancer cells constantly repair their own cell ... Views: 233
"Coordinated post-transcriptional modulation of oncogene-induced senescence by UNR/CSDE1," according to a study published in Cell Reports (Jan. 11), shows an important molecular mechanism that underpins the body's natural protection against skin cancer development. This study sheds fresh light ... Views: 308
In recent years, antibody drugs have undergone explosive development and occupied an increasing proportion in the market of drugs. The high specific affinity of monoclonal antibody against tumor cell antigen making it an ideal carrier for targeted drug delivery, which can be used to target ... Views: 278
A review paper was published in the journal Nature Reviews Drug Discovery on January 13, 2022: Despite the fact that the familiar "-mab" has retired, it marks a new era in antibody drug development.
In November 2021, the WHO updated the generic naming rule for antibody drugs, three years ... Views: 472
A research team from China has developed an mRNA-based T-cell-inducing antigen vaccine that strengthens the COVID-19 vaccine against SARS-CoV-2 variants.
Herd immunity through mass vaccination is an effective way to prevent infectious diseases. However, the common SARS-CoV-2 mutant strains ... Views: 176
Immunometabolism involves glycolysis, tricarboxylic acid cycle, and pentose phosphate pathway and amino acid metabolism and other intracellular metabolic pathways, which play a vital role in regulating immune cell responses. In particular, the metabolism of amino acids such as tryptophan (Trp), ... Views: 189
Hepatitis B virus (HBV) infects around 257 to 291 million people worldwide.
The liver is vital to the health of the human body. Excessive drinking, drugs, medicines, and other viruses can cause damage to the liver. Once the liver is damaged, it will not function properly and people will ... Views: 760
Obsessive-compulsive disorder (OCD) is a serious and common psychiatric disorder with a prevalence of approximately 1-3% in adults. The onset of OCD has a bimodal age distribution, usually manifesting first in late childhood and early adolescence and later appearing in early adulthood. OCD is a ... Views: 415
The outbreak of the COVID-19 epidemic in 2020 brought unprecedented attention to the in vitro diagnostics (IVD) industry.
At present, there are two main types of detection products for COVID-19 used internationally, which are molecular diagnosis (nucleic acid detection) and immunodiagnosis ... Views: 293
Organoids, 3D "micro-organ models" that are prepared from different types of stem cells through self-organization, can simulate the structure and function of native organs. Organoids represent an innovative technology that covers the physiological processes of the entire organism, having a ... Views: 208
AIDS, Acquired Immune Deficiency Syndrome, is a malignant infectious disease with a very high fatality rate caused by HIV (human immunodeficiency virus). HIV invades the human body and can destroy the human immune system, causing the infected person to gradually lose the ability to resist ... Views: 355
Although the prevailing view remains that β-amyloid (Aβ) is key in the pathogenesis of AD, and there is considerable research evidence to support this, the progression of AD brain atrophy is associated with the accumulation of only one other pathological marker, tau protein.
Recently, a study ... Views: 230
Alzheimer's disease is a neurodegenerative disease with insidious onset and progressive development, of which the clinical features are mainly cognitive impairment, abnormal mental behavior, and decline in social life function. Generally, early onset usually occurs before the age of 65. A family ... Views: 207
PROTAC is a novel type of drug that is different from antibodies and traditional small molecule inhibitors, consisting of a linker and two warheads. One end of the PROTAC molecule binds to the target protein, and the other binds to the E3 ubiquitin ligase that can mark the target protein as ... Views: 229
Craig Crews et al. presented the notion of PROTAC (Proteolysis Targeting Chimera: https://www.creative-biolabs.com/protac/) in 2001 to reduce protein levels instead of blocking protein function by exploiting the body's naturally occurring protein cleanup system to treat disease. PROTAC ... Views: 283
"Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity", published by a team of researchers from the Massachusetts Institute of Technology (MIT) in Nature Biomedical Engineering on January 10, 2022.
Attacking tumors by stimulating the ... Views: 247
As the SARS-CoV-2 continues to mutate, virus variants and associated vaccine have become the focus of attention. On August 13, a study of a team of scientists who identified super antibodies from recovered patients, published in the prestigious journal Science, found that those patients carried ... Views: 259
A few days ago, Arvinas, which is committed to developing targeted protein degradation therapies, announced at the American Association for Cancer Research (AACR) annual meeting the molecular structure and pharmacochemical optimization process of two PROTAC based therapies entering the clinical ... Views: 234
In a new study, researchers from the Scripps Research Institute, the University of Virginia and the University of Washington used advanced imaging methods to reveal how production of the Alzheimer's disease-associated protein amyloid beta (Aβ) in the brain is tightly regulated by ... Views: 684
RNA drugs directly interfere with the process of gene transcription and translation, the essence of which is gene therapy. Traditional gene therapy in a narrow sense generally refers to directly modifying the disease-causing genes of target cells or introducing foreign copies of normal genes. ... Views: 207
There are three key points in RNA drug R&D.
First, the immunogenicity of RNA drugs: Because foreign RNA will be recognized by the immune system as a signal of virus interference, RNA drugs will more or less stimulate the immune system and cause a series of side effects.
Second, the ... Views: 201
Insulin injections are currently one of the most popular diabetes treatment options, particularly for persons with type 1 diabetes who require daily insulin injections to keep their blood sugar levels under control. Researchers have claimed to have invented an implantable intraperitoneal ... Views: 271
N-chain protein glycosylation in the brain is an understudied aspect of glucose utilization that affects a variety of cellular processes, including resting membrane potential, axonal activation, and synaptic vesicle transport. In a recent study published in the journal Alzheimer's & DementiaIn ... Views: 383
NKG2A (NK cell lectin-like receptor subfamily C member 1)
Molecular Alias: NKG2A (https://www.creative-biolabs.com/magic-antibody-discovery-human-nkg2a-cd159a-94-233-membrane-protein-partial-his-tag-4490.htm), CD159a, KLRC1, NK cell receptor A
Background:
NKG2A/B/C/D/E/F are members of the ... Views: 287
For cat lovers, the most tragic thing is probably the cat allergy. As soon as you get close to the cat, you sneeze, have a runny nose, or itchy eyes, skin rashes, and even asthma attacks.
There are many people who are allergic to cats, with about 1 in 10 in the population. In some areas, as ... Views: 257
G protein-coupled receptors (GPCRs) play an important role in cellular signaling and serve as important therapeutic targets for a variety of diseases. Upon binding to extracellular agonists, GPCRs stimulate distinct signaling pathways by recruiting different G proteins (Gs, Gi, Gq, etc.,) to ... Views: 165
Nature issued an editorial on July 27, 2021, reflecting on recent topical reporting on AlphaFold.
Our understanding of protein folding will be altered as a result of machine learning. It is important that all data be made available to the public.
"I never imagined we'd make it this far in ... Views: 297