Recently, a report published in the Journal of Fungi showed that the first cases of infection with the deadly super fungus Candida Auris (C. Auris) were found in the COVID-19 intensive care unit (ICU) of a Brazilian hospital.
C. Auris ... Views: 246
Penicillin is an important antibiotic with high efficiency, low toxicity, and wide clinical application.
At the beginning of the 20th century, there were no drug to treat bacterial infections with low side effects. By chance, the British biochemist Alexander Fleming discovered penicillin. In ... Views: 329
Monoclonal antibodies, mRNA/DNA vaccines, CAR-T cells, etc., are popular biological products nowadays, which play an important role in disease prevention and treatment. Most of these technologies originated in the 1980s, which are independent of each other and developed in concert to jointly ... Views: 282
According to real-time data from Johns Hopkins University, as of January 25, the total number of confirmed cases of COVID-19 around the world was 99.269 million, with 25.128 million in the United States, India ranking second with 10.668 million, accounting for 25.3% and 10.7% individually of ... Views: 301
COVID-19 ravaged the world and caused huge losses to human society, but it has accelerated the research and development of mRNA drugs. Some people call 2020 "the first year of mRNA technology."
Progress in mRNA drug development
In 1990, Wolff et al. demonstrated for the first time that ... Views: 264
10 ADC drugs have been approved by the FDA for the treatment of various cancers including hematological tumors and solid tumors in a decade since 2010. Of the 10 ADC drugs currently on the market, 7 have been approved in the last three or four years. Such intensive approval has made ADC the ... Views: 185
Immunotherapy (https://www.creative-biolabs.com/immuno-oncology/) has been successfully applied clinically to treat a wide range of hematological and solid metastatic malignancies. The most widely used drugs targeting immune checkpoints, such as programmed cell death protein 1 (PD-1) and its ... Views: 265
The advent of immune checkpoint inhibitors (ICI) has improved the overall survival of patients with a variety of malignancies. However, the problem of drug resistance to ICI therapy (https://immune-checkpoint.creative-biolabs.com/immune-checkpoint-therapy.htm) remains a major obstacle limiting ... Views: 313
Unplanned pregnancy has always been a source of frustration, and researchers have worked diligently to create a range of contraceptive techniques.
There are several types of contraception available for women, which may be described as hormonal contraception and barrier contraception.
* ... Views: 258
Recently, a paper titled "Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity" was published online in the international journal Cell Metabolism by scientists from Swansea University and other institutions. They found that canagliflozin may potentially be ... Views: 184
Scientists from MIT and the Broad Institute have leveraged an existing bacterial system to create a novel strategy for protein delivery that is effective in both human and animal cells. This technique may be used to target certain cell types for the delivery of a wide range of proteins, ... Views: 156
Gamma herpes viruses, including KSHV and EBV, are clinically associated with the development of various malignancies such as Kaposi's sarcoma, primary exudative lymphoma, and nasopharyngeal carcinoma. Gamma herpes viruses have a biphasic life cycle, namely the latent infection phase and the ... Views: 221
Immunotherapy (https://www.creative-biolabs.com/immuno-oncology/) has gained full attention around the world, which gradually becomes the mainstream cancer treatment. As the key executor of the downstream effects of the immune response, macrophages play an important role in the immune response ... Views: 230
Traditional chemotherapeutics work by killing actively growing cells, but cannot accurately identify tumor cells. Therefore, when the tumor cells are killed, normal cells are also destroyed, resulting in larger adverse reactions.
With the development of modern medicine, traditional extensive ... Views: 273
Cancer is a significant global public health concern. Due to variables such as nutrition, the environment, and the aging of the population, the global prevalence of cancer has increased in recent years, and cancer is gaining prominence as the main cause of death.
Chemotherapy, radiation ... Views: 219
In recent years, nanotechnology and nanotherapy have exerted a profound impact on many fields of medicine, of which the biggest contribution in cancer is mainly derived from the development of new drug delivery systems, including liposomes, nanoparticles, and antibody-drug conjugates (ADCs). ... Views: 166
ADC targeting Trop-2
Trophoblast cell surface antigen 2 (Trop-2) is a transmembrane glycoprotein encoded by the tumor-associated calcium signal transducer 2 (TACSTD2) gene located in the 1p32 region of chromosome, and is a new target for the treatment of solid tumors. It acts as a calcium ... Views: 182
December 24, 2021—Accutar Biotechnology, a biotechnology company focused on AI drug development, announced that the FDA has approved its IND for AC0176 for the treatment of patients with metastatic decompensated refractory prostate cancer (mCRPC).
AC0176 is an orally administered chimeric ... Views: 243
There is concern that the United States will be attacked by another "viral cruise ship" following the spread of SARS-CoV-2. While on a sightseeing cruise from February 26th to March 5th, 2019, 284 guests and 34 crew members aboard the Ruby Princess reported feeling unwell. Patients mostly ... Views: 242
According to the Associated Press, India's southern state of Kerala is rapidly ramping up efforts to halt an outbreak of the deadly Nipah virus, despite the fact that the state is currently battling SARS-CoV-2 that poses a greater threat.
Kerala was put on high alert when a 12-year-old boy ... Views: 267
Pain receptors are a type of sensory neuron (https://neuros.creative-biolabs.com/foundations-of-neurosciences.htm) that alerts us to potentially harmful environmental changes or stimuli, such as extreme heat or stress. Their signals are converted into pain feelings in the brain. Specific forms ... Views: 296
HBV (https://www.creativebiolabs.net/symbolsearch_HBV.htm) generates free covalently closed circular DNA (cccDNA) and exists in the nucleus of infected cells, which is the only known pregenomic RNA (pgRNA) template, as well as a template for viral protein transcription and viral replication. As ... Views: 242
Antibody discovery includes two procedures, antibody screening and optimization. Antibody screening is to search for high-quality antibody candidates from the beginning, and antibody optimization is to make necessary improvements to existing antibodies. Antibody discovery is the only way to ... Views: 187
Antibody Library
According to the source and use of antibody genes, antibody libraries are divided into immune antibody library (https://www.creative-biolabs.com/immune-antibody-library-services.html) and general antibody library. The antibody genes of the immune antibody library are derived ... Views: 215
Daiichi Sankyo and AstraZeneca recently announced that in the global phase 3 clinical trial—DESTINY-The Gastric04 (NCT04704934), the first patient was given a drug treatment to evaluate the HER2-targeting ADC (https://www.creative-biolabs.com/adc/target-erbb2-37.htm) Enhertu (fam-trastuzumab ... Views: 221
Researchers such as Mansun Law of The Scripps Research Institute discovered that rhesus monkeys can produce a convergent antibody response to HCV envelope glycoprotein.
The paper entitled "Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques ... Views: 240
Phage display technology is a powerful gene expression screening technology, which was first described by SmithMl et al. in Science in 1985. The basic principle is to clone the gene of the foreign protein into the genomic DNA of the phage, thereby expressing the specific foreign protein on the ... Views: 228
Recently, scientists at Stanford University published a gene sequencing file of Moderna's COVID-19 vaccine on the open-source code repository GitHub, deciphering the mRNA sequence of the vaccine for the first time. The release immediately captured the headlines of major science and technology ... Views: 608
Pancreatic cancer is a highly malignant tumor of the digestive tract that is difficult to diagnose and treat. 90% of the subtypes are pancreatic ductal adenocarcinoma (PDAC).
In recent years, the incidence and mortality of pancreatic cancer have increased significantly. The early diagnosis ... Views: 227
Globally, around 3 billion cups of coffee are drank daily, according to estimates. Due to its high caffeine concentration, it is frequently used to enhance alertness and productivity. Past research has demonstrated that frequent coffee drinking is associated with a number of health ... Views: 238
With the increasingly fierce competition in the field of oncology drug R&D, the exploration of various drug forms based on established drug targets is a relatively low-risk R&D option. However, the commercialized drug targets that have been successfully operated are already very competitive. ... Views: 190
Johnson & Johnson announced the Phase 3 ENSEMBLE clinical trial data of topline efficacy and safety, demonstrating that the investigational single-dose COVID-19 vaccine developed by Janssen met all primary and key secondary endpoints. The data are based on 43,783 participants accruing 468 ... Views: 313
Stanniocalcin-1 (STC1) is a glycoprotein hormone(https://www.creative-biolabs.com/glycoprotein/) involved in calcium/phosphate homeostasis that regulates a variety of cellular processes during normal development and tumorigenesis. After analyzing more than 1,000 genes, researchers at the ... Views: 507
In the Journal of Controlled Release, Vol. 336, 2021, Islam A. Khalil's research group from the Misr University for Science and Technology (Egypt) published a review article titled "Cancer immunotherapy from biology to nanomedicine."
Cancer is one of the most common causes of mortality in ... Views: 309
Vaccines have traditionally been used to prevent infectious diseases, whose ability to induce and amplify antigen-specific immune responses has long been considered a potentially valuable tool for the treatment of cancer. Early therapeutic vaccination strategies focused on the abnormally ... Views: 224
In recent years, CAR-T cell therapy has become one of the most promising treatments for hematologic malignancies and autoimmune diseases. The immunosuppressive environment and T-cell dysfunction that CAR-T cells face in vivo are the main factors contributing to suboptimal CAR-T cell therapy. ... Views: 18
In this era of "superbugs" floods, phage therapy has re-entered public vision. Although there have been many cases of patients with "superbugs" infection being cured by phage, there are still some challenges in phage therapy.
Quality and safety requirements
The success of phage therapy ... Views: 217
Currently, the number of COVID-19 confirmed cases has exceeded 147 million, and the death exceeded 2 million. The rapid spread of COVID-19 prompts the healthcare community to explore potential treatments, by investigating the drugs that are already approved and developing innovative therapies ... Views: 216
In this article, we'll continue talking about the nAb drugs that have entered the clinical trials.
LY-CoV555 and LY-CoV016
LY-CoV555 (also known as LY3819253, recently named bamlanivimab) is a fully human neutralizing IgG1 mAb developed by AbCellera and the National Institute of Allergy ... Views: 217
In this article, we'll continue talking about the nAb drugs that have entered clinical trial.
REGN-COV2
REGN-COV2 is a new type of mixture composed of two mAbs (REGN10987 and REGN10933, recently named imdevimab and casirivimab, respectively) for the treatment of COVID-19 patients and the ... Views: 154
Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers. Globally, liver cancer is the fourth leading cause of cancer-related deaths and sixth in the number of new cases. The 5-year survival rate of liver cancer is only 18%, which is the second most lethal tumor after ... Views: 272
Recent research has uncovered an especially aggressive mechanism for the spread of a particularly aggressive type of breast cancer, in which the NUP93 protein plays a key role. Because this protein creates a "tunnel" in the nuclear membrane ... Views: 271
Collagen is the most abundant protein in the human body, which is produced by fibroblasts and exists in bones, tendons, and skin. During the occurrence and development of cancer, collagen tends to accumulate in and around tumors. Therefore, some researchers speculate that collagen helps to ... Views: 248
As commonly used antibody screening technologies, hybridomas and phage display (https://phagenbio.creative-biolabs.com/phage-display-systems.htm) libraries have their own characteristics.
The heavy chain and light chain of hybridoma mAbs derive from a B cell, which is a natural pairing. The ... Views: 209
On March 23, Professor Tang Ruikang from the Department of Chemistry of Zhejiang University, Associate Researcher Wang Xiaoyu from Qiushi Institute of Advanced Studies, and Researcher Hou Lihua from the Institute of Biological Engineering, Institute of Military Medical Research, Academy of ... Views: 220
Since the first proof of concept in 2001, targeted protein degradation induced by small molecules has gradually become a popular direction in drug development. There are two main strategies for inducing degradation. One is to use small molecules that can change the E3 ligase substrate ... Views: 239
Protein is an important component of all cells and tissues of the human body. However, abnormal protein activities in the body may cause problems, such as increasing the risk of cancer and making people age faster.
On July 28, a research report titled "Rewiring of the ubiquitinated proteome ... Views: 234
Recently, when most countries in the world are still struggling with the COVID-19, the Ebola virus (EBOV) that is more deadly, resurfaced.
According to UN News, a funeral was held on February 1 after the death of a nurse in southern Guinea, West Africa, on January 28. Unfortunately, the 6 ... Views: 267
Since the start of the COVID-19 pandemic in early 2020, a series of variants of the SARS-CoV-2 have emerged around the world. In the early stages of the epidemic, a new coronavirus containing a mutation in the spike protein D614G dominated the world. The scientific community generally believes ... Views: 296
In the past few decades, immunotherapy has been at the forefront of cancer treatment. Accompanying the continuing development of tumor immunotherapy for centuries, there are many important discoverers.
As early as 1777, people tried to inject various pathogens to elicit an immune response ... Views: 301