Hepatitis B virus (HBV) infects around 257 to 291 million people worldwide.
The liver is vital to the health of the human body. Excessive drinking, drugs, medicines, and other viruses can cause damage to the liver. Once the liver is damaged, it will not function properly and people will ... Views: 763
In a new study, researchers from the Scripps Research Institute, the University of Virginia and the University of Washington used advanced imaging methods to reveal how production of the Alzheimer's disease-associated protein amyloid beta (Aβ) in the brain is tightly regulated by ... Views: 686
Recently, scientists at Stanford University published a gene sequencing file of Moderna's COVID-19 vaccine on the open-source code repository GitHub, deciphering the mRNA sequence of the vaccine for the first time. The release immediately captured the headlines of major science and technology ... Views: 620
Sweet sensations can be induced by both sucrose and artificial sweeteners, but animals and humans prefer the former. Even mice without taste receptors are able to distinguish between sucrose and sweets. Although the tongue is responsible for sweetness perception, the duodenum is crucial in ... Views: 613
SARS-CoV-2 (https://www.antibody-creativebiolabs.com/search.aspx?key=sars-cov-2&ty=product) swept the world in 2020, leading to blockades, social distancing, and huge economic losses. In addition, COVID-19 also triggered vaccine, treatment, and diagnostics competition, achieving the approval of ... Views: 584
Stanniocalcin-1 (STC1) is a glycoprotein hormone(https://www.creative-biolabs.com/glycoprotein/) involved in calcium/phosphate homeostasis that regulates a variety of cellular processes during normal development and tumorigenesis. After analyzing more than 1,000 genes, researchers at the ... Views: 521
A review paper was published in the journal Nature Reviews Drug Discovery on January 13, 2022: Despite the fact that the familiar "-mab" has retired, it marks a new era in antibody drug development.
In November 2021, the WHO updated the generic naming rule for antibody drugs, three years ... Views: 475
Whether it is a superhero in "The Avengers" or a vampire in "Twilight", immortality and eternal youth have always been eye-catching topics, which represent the ultimate dream of mankind. Scientists have also spent decades trying to use the power of genomics and artificial intelligence to find a ... Views: 422
Obsessive-compulsive disorder (OCD) is a serious and common psychiatric disorder with a prevalence of approximately 1-3% in adults. The onset of OCD has a bimodal age distribution, usually manifesting first in late childhood and early adolescence and later appearing in early adulthood. OCD is a ... Views: 417
The most common neurodegenerative disease is Alzheimer's disease (AD), often known as dementia. The loss of memory, learning ability, emotional regulation, and athletic ability is common in patients, all of which have a negative impact on health, families, and society.
Currently, about 50 ... Views: 389
N-chain protein glycosylation in the brain is an understudied aspect of glucose utilization that affects a variety of cellular processes, including resting membrane potential, axonal activation, and synaptic vesicle transport. In a recent study published in the journal Alzheimer's & DementiaIn ... Views: 385
AIDS, Acquired Immune Deficiency Syndrome, is a malignant infectious disease with a very high fatality rate caused by HIV (human immunodeficiency virus). HIV invades the human body and can destroy the human immune system, causing the infected person to gradually lose the ability to resist ... Views: 355
The most commonly used murine monoclonal antibodies (mAbs) have played a crucial role in clinical diagnosis and treatment, which, however, have strong immunogenicity and can cause human anti-mouse antibody (HAMA) reactions in clinical applications, resulting in shorter antibody half-life (less ... Views: 352
On February 22, FiercePharma selected the 10 most anticipated new drugs on the market in 2021 based on the estimated global new drug sales data for 2026 by Evaluate Pharma. Among them, Biogen's Aducanumab, an Alzheimer's drug candidate leads the list. Other diseases such as psoriasis, KRAS G12C ... Views: 345
The use of immune checkpoint inhibitors (ICIs) has become the most important achievement in oncology in the last decade. From a more holistic viewpoint, it is a powerful clinical strategy.
Cancer cells are transformed from normal cells, and through altering the tumor immune milieu, the ... Views: 344
Penicillin is an important antibiotic with high efficiency, low toxicity, and wide clinical application.
At the beginning of the 20th century, there were no drug to treat bacterial infections with low side effects. By chance, the British biochemist Alexander Fleming discovered penicillin. In ... Views: 336
By 2040, pancreatic ductal adenocarcinoma (PDAC) is projected to become the second most fatal kind of cancer in humans, and the majority of patients with PDAC will not respond to chemotherapy according to existing treatment protocols. Scientists have identified diet as an environmental element ... Views: 334
The advent of immune checkpoint inhibitors (ICI) has improved the overall survival of patients with a variety of malignancies. However, the problem of drug resistance to ICI therapy (https://immune-checkpoint.creative-biolabs.com/immune-checkpoint-therapy.htm) remains a major obstacle limiting ... Views: 327
In the Journal of Controlled Release, Vol. 336, 2021, Islam A. Khalil's research group from the Misr University for Science and Technology (Egypt) published a review article titled "Cancer immunotherapy from biology to nanomedicine."
Cancer is one of the most common causes of mortality in ... Views: 321
Johnson & Johnson announced the Phase 3 ENSEMBLE clinical trial data of topline efficacy and safety, demonstrating that the investigational single-dose COVID-19 vaccine developed by Janssen met all primary and key secondary endpoints. The data are based on 43,783 participants accruing 468 ... Views: 319
The haze of the COVID-19 epidemic still hangs over human society and has yet to subside. As the northern hemisphere enters the cold season and a new mutant strain of Omicron emerges, a new wave of neo-crown epidemics seems to be emerging.
Since the approval of the first vaccine in early 2020, ... Views: 317
Seagne and Genmab announced on September 20, 2021 that Tisotumab Vedotin has received accelerated approval from the FDA for the treatment of recurring or metastatic cervical cancer.
Tivdak (Tisotumab vedotin-tftv) is an ADC produced by combining Genmab's tissue factor (TF) monoclonal antibody ... Views: 313
In the past few decades, immunotherapy has been at the forefront of cancer treatment. Accompanying the continuing development of tumor immunotherapy for centuries, there are many important discoverers.
As early as 1777, people tried to inject various pathogens to elicit an immune response ... Views: 309
"Coordinated post-transcriptional modulation of oncogene-induced senescence by UNR/CSDE1," according to a study published in Cell Reports (Jan. 11), shows an important molecular mechanism that underpins the body's natural protection against skin cancer development. This study sheds fresh light ... Views: 309
According to real-time data from Johns Hopkins University, as of January 25, the total number of confirmed cases of COVID-19 around the world was 99.269 million, with 25.128 million in the United States, India ranking second with 10.668 million, accounting for 25.3% and 10.7% individually of ... Views: 307
Pain receptors are a type of sensory neuron (https://neuros.creative-biolabs.com/foundations-of-neurosciences.htm) that alerts us to potentially harmful environmental changes or stimuli, such as extreme heat or stress. Their signals are converted into pain feelings in the brain. Specific forms ... Views: 306
Since the start of the COVID-19 pandemic in early 2020, a series of variants of the SARS-CoV-2 have emerged around the world. In the early stages of the epidemic, a new coronavirus containing a mutation in the spike protein D614G dominated the world. The scientific community generally believes ... Views: 303
Researchers at the University of Helsinki have devised a new technique for returning human cells to a stem cell state that is faster and more reliable.
Pluripotent stem cells, which can differentiate into any cell in the body and can generate all tissues and organs, are the present focus of ... Views: 300
Moderna launched a clinical study for an HIV mRNA vaccine in August 2021, on 56 HIV-negative people aged 18 to 50.
AIDS is a highly contagious disease. In 2020, the United Nations estimates that 37.7 million people would be living with HIV around the world. However, there is currently no ... Views: 298
Nature issued an editorial on July 27, 2021, reflecting on recent topical reporting on AlphaFold.
Our understanding of protein folding will be altered as a result of machine learning. It is important that all data be made available to the public.
"I never imagined we'd make it this far in ... Views: 298
In the field of tumor therapy, antibody-drug conjugate (ADC) with both targeting and strong activities has gradually become the new focus of the industry due to its excellent performance in many indications, and it is known as "the rising star of tumor therapy".
What is ADC
Traditional ADC ... Views: 298
Immunotherapy, in addition to surgery, chemotherapy, and radiotherapy, has now become the fourth pillar of anticancer treatment, with T cell-based immunotherapy being a successful cancer treatment technique. T cells can be separated into two subpopulations based on the expression of T-cell ... Views: 296
Antibody-drug conjugate (ADC: https://www.creative-biolabs.com/adc/), a compound that connects a cytotoxic small-molecule drug to a monoclonal antibody via a rationally established linker, which selectively delivers an efficient cytotoxic agent into the tumor, has made significant progress in ... Views: 294
The outbreak of the COVID-19 epidemic in 2020 brought unprecedented attention to the in vitro diagnostics (IVD) industry.
At present, there are two main types of detection products for COVID-19 used internationally, which are molecular diagnosis (nucleic acid detection) and immunodiagnosis ... Views: 293
Recently, India approved a new COVID-19 vaccine, ZyCoV-D, which uses a circular DNA strand to stimulate the immune system against the SARS-CoV-2. The approval of ZyCoV-D as the world's first DNA vaccine for humans heralds the arrival of DNA vaccines against various diseases.
According to ... Views: 292
Monoclonal antibodies, mRNA/DNA vaccines, CAR-T cells, etc., are popular biological products nowadays, which play an important role in disease prevention and treatment. Most of these technologies originated in the 1980s, which are independent of each other and developed in concert to jointly ... Views: 291
Antibody-drug conjugates (ADCs) have made great progress in the past 10 years, which are a complex that has cytotoxic small-molecule drug coupled to a monoclonal antibody (mAb) through a reasonably placed linker. It can selectively deliver effective cytotoxic drugs into the tumor.
In 2009, ... Views: 290
NKG2A (NK cell lectin-like receptor subfamily C member 1)
Molecular Alias: NKG2A (https://www.creative-biolabs.com/magic-antibody-discovery-human-nkg2a-cd159a-94-233-membrane-protein-partial-his-tag-4490.htm), CD159a, KLRC1, NK cell receptor A
Background:
NKG2A/B/C/D/E/F are members of the ... Views: 289
Craig Crews et al. presented the notion of PROTAC (Proteolysis Targeting Chimera: https://www.creative-biolabs.com/protac/) in 2001 to reduce protein levels instead of blocking protein function by exploiting the body's naturally occurring protein cleanup system to treat disease. PROTAC ... Views: 285
Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers. Globally, liver cancer is the fourth leading cause of cancer-related deaths and sixth in the number of new cases. The 5-year survival rate of liver cancer is only 18%, which is the second most lethal tumor after ... Views: 283
Recent research has uncovered an especially aggressive mechanism for the spread of a particularly aggressive type of breast cancer, in which the NUP93 protein plays a key role. Because this protein creates a "tunnel" in the nuclear membrane ... Views: 283
Recently, Samir Mitragotri's team published a review in Nature Biomedical Engineering, systematically summarizing five types of therapeutic drugs, which are small molecules, nucleic acids, peptides, proteins, and cells, as well as related drug delivery challenges and three measures taken to face ... Views: 282
In recent years, antibody drugs have undergone explosive development and occupied an increasing proportion in the market of drugs. The high specific affinity of monoclonal antibody against tumor cell antigen making it an ideal carrier for targeted drug delivery, which can be used to target ... Views: 280
Traditional chemotherapeutics work by killing actively growing cells, but cannot accurately identify tumor cells. Therefore, when the tumor cells are killed, normal cells are also destroyed, resulting in larger adverse reactions.
With the development of modern medicine, traditional extensive ... Views: 279
According to the Associated Press, India's southern state of Kerala is rapidly ramping up efforts to halt an outbreak of the deadly Nipah virus, despite the fact that the state is currently battling SARS-CoV-2 that poses a greater threat.
Kerala was put on high alert when a 12-year-old boy ... Views: 276
In 1958, Francis Crick proposed the famous "Central Dogma", thereby constructing a large framework for the transmission of biological genetic information, namely "DNA→RNA→Protein". Of course, as a theory, the central principle is often questioned and misunderstood, e.g., RNA can also be written ... Views: 276
In the process of preclinical development, a compound or biological agent must go through the testing phases, for the following targets, which are the identification of potential targets of disease treatment and screening out the potential candidates that must go through toxicity test before ... Views: 276
COVID-19 ravaged the world and caused huge losses to human society, but it has accelerated the research and development of mRNA drugs. Some people call 2020 "the first year of mRNA technology."
Progress in mRNA drug development
In 1990, Wolff et al. demonstrated for the first time that ... Views: 275
Immunotherapy (https://www.creative-biolabs.com/immuno-oncology/) has been successfully applied clinically to treat a wide range of hematological and solid metastatic malignancies. The most widely used drugs targeting immune checkpoints, such as programmed cell death protein 1 (PD-1) and its ... Views: 275
The advent of the era of precision medicine takes monoclonal antibody (mAb) drugs that have high specificity and effectiveness to a hot spot in biological drug therapy.
In 1975, Georges Köhler and César Milstein successfully invented hybridoma technology, laying the foundation for monoclonal ... Views: 274