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Articles from Jerry Carter | Selfgrowth.com
- A "miracle" fruit that can enhance the immune response to tumors - by Submitted on Mar 06, 2022 from Jerry CarterThe advent of immune checkpoint inhibitors (ICI) has improved the overall survival of patients with a variety of malignancies. However, the problem of drug resistance to ICI therapy (https://immune-checkpoint.creative-biolabs.com/immune-checkpoint-therapy.htm) remains a major obstacle limiting ...
Views: 102 - Gamma delta T cells in tumor immunotherapy - by Submitted on Mar 06, 2022 from Jerry CarterImmunotherapy, in addition to surgery, chemotherapy, and radiotherapy, has now become the fourth pillar of anticancer treatment, with T cell-based immunotherapy being a successful cancer treatment technique. T cells can be separated into two subpopulations based on the expression of T-cell ...
Views: 98 - Closing the "tunnel of cells" to slow cancer - by Submitted on Mar 06, 2022 from Jerry CarterRecent research has uncovered an especially aggressive mechanism for the spread of a particularly aggressive type of breast cancer, in which the NUP93 protein plays a key role. Because this protein creates a "tunnel" in the nuclear membrane ...
Views: 104 - OCD: an "autoimmune disease" - by Submitted on Mar 06, 2022 from Jerry CarterObsessive-compulsive disorder (OCD) is a serious and common psychiatric disorder with a prevalence of approximately 1-3% in adults. The onset of OCD has a bimodal age distribution, usually manifesting first in late childhood and early adolescence and later appearing in early adulthood. OCD is a ...
Views: 125 - Three generations of ADC: Nearly a decade of development-PI - by Submitted on Mar 06, 2022 from Jerry CarterAntibody-drug conjugate (ADC: https://www.creative-biolabs.com/adc/), a compound that connects a cytotoxic small-molecule drug to a monoclonal antibody via a rationally established linker, which selectively delivers an efficient cytotoxic agent into the tumor, has made significant progress in ...
Views: 127 - Too much sugar consumed at a young age can harm the brain and lead to mental disorders - by Submitted on Feb 08, 2022 from Jerry CarterSugar is a direct source of sweetness that not only enhances the flavor of food but also serves as a source of energy for the body. Sugar is used in everyday life to give us a "sweet" feeling, whether it's in candy, cake, or cola. Sugar consumption is quickly increasing as material living ...
Views: 105 - New Naming Rules for Antibodies: Dropping the "-mAb" Stem - by Submitted on Feb 07, 2022 from Jerry CarterA review paper was published in the journal Nature Reviews Drug Discovery on January 13, 2022: Despite the fact that the familiar "-mab" has retired, it marks a new era in antibody drug development. In November 2021, the WHO updated the generic naming rule for antibody drugs, three years ...
Views: 166 - New discovery! The "dual personality" protein is both a "firewall" against cancer and a "promoter" of cancer! - by Submitted on Feb 07, 2022 from Jerry Carter"Coordinated post-transcriptional modulation of oncogene-induced senescence by UNR/CSDE1," according to a study published in Cell Reports (Jan. 11), shows an important molecular mechanism that underpins the body's natural protection against skin cancer development. This study sheds fresh light ...
Views: 127 - Immune Checkpoint Inhibitors: Where Do They Go From Here? - by Submitted on Feb 07, 2022 from Jerry CarterThe use of immune checkpoint inhibitors (ICIs) has become the most important achievement in oncology in the last decade. From a more holistic viewpoint, it is a powerful clinical strategy. Cancer cells are transformed from normal cells, and through altering the tumor immune milieu, the ...
Views: 135 - Putting the gas on the immune system! - by Submitted on Feb 07, 2022 from Jerry Carter"Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity", published by a team of researchers from the Massachusetts Institute of Technology (MIT) in Nature Biomedical Engineering on January 10, 2022. Attacking tumors by stimulating the ...
Views: 92 - Intestinal optogenetics elucidates the neurobiological mechanism of sucrose preference in the intestine - by Submitted on Feb 07, 2022 from Jerry CarterSweet sensations can be induced by both sucrose and artificial sweeteners, but animals and humans prefer the former. Even mice without taste receptors are able to distinguish between sucrose and sweets. Although the tongue is responsible for sweetness perception, the duodenum is crucial in ...
Views: 209 - Improved Gene Editing Technology for Stem Cell Study! - by Submitted on Feb 07, 2022 from Jerry CarterResearchers at the University of Helsinki have devised a new technique for returning human cells to a stem cell state that is faster and more reliable. Pluripotent stem cells, which can differentiate into any cell in the body and can generate all tissues and organs, are the present focus of ...
Views: 101 - A "bad" bacteria in colon cancer may serve a "positive" role in tumor immunity - by Submitted on Jan 04, 2022 from Jerry CarterImmunotherapy (https://www.creative-biolabs.com/immuno-oncology/) has been successfully applied clinically to treat a wide range of hematological and solid metastatic malignancies. The most widely used drugs targeting immune checkpoints, such as programmed cell death protein 1 (PD-1) and its ...
Views: 108 - Scientists mapped glycosylation patterns associated with the onset of Alzheimer's disease in humans - by Submitted on Jan 04, 2022 from Jerry CarterN-chain protein glycosylation in the brain is an understudied aspect of glucose utilization that affects a variety of cellular processes, including resting membrane potential, axonal activation, and synaptic vesicle transport. In a recent study published in the journal Alzheimer's & DementiaIn ...
Views: 138 - New Cell study uncovers why mRNA vaccines are so effective against COVID-19 - by Submitted on Jan 04, 2022 from Jerry CarterThe haze of the COVID-19 epidemic still hangs over human society and has yet to subside. As the northern hemisphere enters the cold season and a new mutant strain of Omicron emerges, a new wave of neo-crown epidemics seems to be emerging. Since the approval of the first vaccine in early 2020, ...
Views: 130 - Status of NKG2A-targeting drugs under research—PART I - by Submitted on Jan 04, 2022 from Jerry CarterNKG2A (NK cell lectin-like receptor subfamily C member 1) Molecular Alias: NKG2A (https://www.creative-biolabs.com/magic-antibody-discovery-human-nkg2a-cd159a-94-233-membrane-protein-partial-his-tag-4490.htm), CD159a, KLRC1, NK cell receptor A Background: NKG2A/B/C/D/E/F are members of the ...
Views: 114 - Viagra may help to prevent Alzheimer's disease - by Submitted on Jan 03, 2022 from Jerry CarterThe most common neurodegenerative disease is Alzheimer's disease (AD), often known as dementia. The loss of memory, learning ability, emotional regulation, and athletic ability is common in patients, all of which have a negative impact on health, families, and society. Currently, about 50 ...
Views: 136 - Anthrax toxin, lethal, but can be used to relieve pain - by Submitted on Jan 03, 2022 from Jerry CarterPain receptors are a type of sensory neuron (https://neuros.creative-biolabs.com/foundations-of-neurosciences.htm) that alerts us to potentially harmful environmental changes or stimuli, such as extreme heat or stress. Their signals are converted into pain feelings in the brain. Specific forms ...
Views: 118 - Another PROTAC entered clinical study - by Submitted on Jan 03, 2022 from Jerry CarterDecember 24, 2021—Accutar Biotechnology, a biotechnology company focused on AI drug development, announced that the FDA has approved its IND for AC0176 for the treatment of patients with metastatic decompensated refractory prostate cancer (mCRPC). AC0176 is an orally administered chimeric ...
Views: 113 - Firstly Uncovered Genetic Clues to Schizophrenia - by Submitted on Jan 03, 2022 from Jerry CarterCornel University researchers recently made a breakthrough in the study of schizophrenia with human-derived cerebral organoids. Schizophrenia is a chronic brain disorder of hitherto unknown exact etiology, with typical symptoms usually appearing in early adulthood and affecting approximately ...
Views: 102 - What is the severity of the Omicron mutation? - by Submitted on Jan 03, 2022 from Jerry CarterRecently, many scientists around the world summarized what they have learned about Omicron (an emerging variant of SARS-CoV-2) so far, as reported in Nature. Researchers from all over the world are now studying the Omicron strain to learn more about its infectivity, pathogenicity, and immune ...
Views: 106 - PROTAC technology, a powerful tool for innovative drug development—Advantages - by Submitted on Oct 06, 2021 from Jerry CarterCraig Crews et al. presented the notion of PROTAC (Proteolysis Targeting Chimera: https://www.creative-biolabs.com/protac/) in 2001 to reduce protein levels instead of blocking protein function by exploiting the body's naturally occurring protein cleanup system to treat disease. PROTAC ...
Views: 116 - Uncovering the mystery of the origin of Alzheimer's disease: Is the replication of prions in the human brain the culprit? - by Submitted on Oct 06, 2021 from Jerry CarterIn 1958, Francis Crick proposed the famous "Central Dogma", thereby constructing a large framework for the transmission of biological genetic information, namely "DNA→RNA→Protein". Of course, as a theory, the central principle is often questioned and misunderstood, e.g., RNA can also be written ...
Views: 111 - Another zoonotic virus! One case of death from Nipah virus infection in southern India - by Submitted on Oct 06, 2021 from Jerry CarterAccording to the Associated Press, India's southern state of Kerala is rapidly ramping up efforts to halt an outbreak of the deadly Nipah virus, despite the fact that the state is currently battling SARS-CoV-2 that poses a greater threat. Kerala was put on high alert when a 12-year-old boy ...
Views: 118 - The first approved DNA vaccine against SARS-CoV-2—ZyCoV-D - by Submitted on Oct 06, 2021 from Jerry CarterRecently, India approved a new COVID-19 vaccine, ZyCoV-D, which uses a circular DNA strand to stimulate the immune system against the SARS-CoV-2. The approval of ZyCoV-D as the world's first DNA vaccine for humans heralds the arrival of DNA vaccines against various diseases. According to ...
Views: 141 - Uncovering the mystery of the origin of Alzheimer's disease: Is the replication of prions in the human brain the culprit? - by Submitted on Oct 06, 2021 from Jerry CarterIn 1958, Francis Crick proposed the famous "Central Dogma", thereby constructing a large framework for the transmission of biological genetic information, namely "DNA→RNA→Protein". Of course, as a theory, the central principle is often questioned and misunderstood, e.g., RNA can also be written ...
Views: 118 - Say goodbye to injections, magnetic insulin capsules with magnetic positioning are introduced - by Submitted on Oct 06, 2021 from Jerry CarterInsulin injections are currently one of the most popular diabetes treatment options, particularly for persons with type 1 diabetes who require daily insulin injections to keep their blood sugar levels under control. Researchers have claimed to have invented an implantable intraperitoneal ...
Views: 119 - Moderna launched a clinical study for an HIV mRNA vaccine in - by Submitted on Oct 06, 2021 from Jerry CarterModerna launched a clinical study for an HIV mRNA vaccine in August 2021, on 56 HIV-negative people aged 18 to 50. AIDS is a highly contagious disease. In 2020, the United Nations estimates that 37.7 million people would be living with HIV around the world. However, there is currently no ...
Views: 142 - Cancer Cell: Barrier to cancer immunotherapy discovered - by Submitted on Oct 04, 2021 from Jerry CarterStanniocalcin-1 (STC1) is a glycoprotein hormone(https://www.creative-biolabs.com/glycoprotein/) involved in calcium/phosphate homeostasis that regulates a variety of cellular processes during normal development and tumorigenesis. After analyzing more than 1,000 genes, researchers at the ...
Views: 217 - Cancer Immunotherapy Overview - by Submitted on Oct 04, 2021 from Jerry CarterIn the Journal of Controlled Release, Vol. 336, 2021, Islam A. Khalil's research group from the Misr University for Science and Technology (Egypt) published a review article titled "Cancer immunotherapy from biology to nanomedicine." Cancer is one of the most common causes of mortality in ...
Views: 126 - The 12th ADC Drug Approved by the FDA - by Submitted on Oct 04, 2021 from Jerry CarterSeagne and Genmab announced on September 20, 2021 that Tisotumab Vedotin has received accelerated approval from the FDA for the treatment of recurring or metastatic cervical cancer. Tivdak (Tisotumab vedotin-tftv) is an ADC produced by combining Genmab's tissue factor (TF) monoclonal antibody ...
Views: 116 - A major breakthrough has occurred! 99.9% safe contraceptive antibodies are now available - by Submitted on Oct 04, 2021 from Jerry CarterUnplanned pregnancy has always been a source of frustration, and researchers have worked diligently to create a range of contraceptive techniques. There are several types of contraception available for women, which may be described as hormonal contraception and barrier contraception. * ...
Views: 114 - The endocytosis mechanism of ADC drugs: Part II - by Submitted on Oct 04, 2021 from Jerry CarterPit-mediated endocytosis Clathrin-independent endocytosis includes caveolin-mediated endocytosis, caveolin-independent carrier protein/GPI-enriched early inner compartment (CLIC/GEEC), and macropinocytosis. The pit is a vial-like invagination of the plasma membrane, characterized by high ...
Views: 126 - NEJM: Decreased protection efficiency of mRNA and adenovirus vaccines against delta mutant - by Submitted on Sep 06, 2021 from Jerry CarterOn August 12, 2021, data on the efficiency of real-world vaccine protection in the United Kingdom was published in the New England Journal of Medicine (NEJM). Since the global outbreak of the COVID-19 epidemic in early 2020, various mutant strains have continued to emerge, including Alpha ...
Views: 128 - Revealing the mechanism by which brain cholesterol regulates beta-amyloid plaque production in Alzheimer's disease - by Submitted on Sep 06, 2021 from Jerry CarterIn a new study, researchers from the Scripps Research Institute, the University of Virginia and the University of Washington used advanced imaging methods to reveal how production of the Alzheimer's disease-associated protein amyloid beta (Aβ) in the brain is tightly regulated by ...
Views: 283 - Evolutionary Drug Delivery - by Submitted on Sep 06, 2021 from Jerry CarterDrug delivery strategies (https://www.creative-biolabs.com/targeted-delivery/) have greatly facilitated the treatment and application of drugs. The rapid development of therapeutics is dependent on the continuous pursuit of advances in delivery technologies and strategies. Decades ago, small ...
Views: 116 - Detoxification matters! After some insects fully turn on the "detox mode", they can prolong their life by 21% - by Submitted on Sep 06, 2021 from Jerry CarterProtein is an important component of all cells and tissues of the human body. However, abnormal protein activities in the body may cause problems, such as increasing the risk of cancer and making people age faster. On July 28, a research report titled "Rewiring of the ubiquitinated proteome ...
Views: 117 - Structure biology will continue to use artificial intelligence - by Submitted on Sep 02, 2021 from Jerry CarterNature issued an editorial on July 27, 2021, reflecting on recent topical reporting on AlphaFold. Our understanding of protein folding will be altered as a result of machine learning. It is important that all data be made available to the public. "I never imagined we'd make it this far in ...
Views: 162 - Clinical progress of hepatocellular carcinoma (HCC) treatment - by Submitted on Sep 02, 2021 from Jerry CarterHepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers. Globally, liver cancer is the fourth leading cause of cancer-related deaths and sixth in the number of new cases. The 5-year survival rate of liver cancer is only 18%, which is the second most lethal tumor after ...
Views: 130 - Nature: An overview of the development of antibody drugs - by Submitted on Sep 02, 2021 from Jerry CarterIt has been 35 years since the FDA approved the first monoclonal antibody in 1986. Antibody-based drugs account for nearly one-fifth of new FDA drug approvals each year. In this time, antibody engineering (https://www.creative-biolabs.com/engineering-services.html) has changed dramatically. ...
Views: 117 - Recovered patients from COVID-19 contain super antibodies against 13 natural SARS-CoV-2 variants - by Submitted on Sep 02, 2021 from Jerry CarterAs the SARS-CoV-2 continues to mutate, virus variants and associated vaccine have become the focus of attention. On August 13, a study of a team of scientists who identified super antibodies from recovered patients, published in the prestigious journal Science, found that those patients carried ...
Views: 143 - The endocytosis mechanism of ADC drugs: Part I - by Submitted on Sep 02, 2021 from Jerry CarterAntibody-drug conjugates (ADCs) have made great progress in the past 10 years, which are a complex that has cytotoxic small-molecule drug coupled to a monoclonal antibody (mAb) through a reasonably placed linker. It can selectively deliver effective cytotoxic drugs into the tumor. In 2009, ...
Views: 135 - Interaction Among Phage, Bacteria, and Health - by Submitted on Aug 28, 2021 from Jerry CarterWhat are the effects of bacteriophages on the body's immune system? Bacteriophages cannot infect eukaryotic cells, but more and more studies have shown that phages can regulate the immune response of mammals. Especially when the phage and the host bacteria ...
Views: 111 - Evolution of Tumor Immunotherapy: PII - by Submitted on Aug 28, 2021 from Jerry CarterAnti-tumor Monoclonal Antibody (mAb) The concept that cancer cells express certain potential target antigens paves the way for humanized antibodies as a therapeutic strategy for malignant tumors. Antibodies can interact with immune cells through the Fc domain of antibodies to target and destroy ...
Views: 126 - Live Vaccines Against Malaria - by Submitted on Aug 04, 2021 from Jerry CarterFor a long time, malaria is one of the most serious diseases threatening human health. According to the WHO, there were 229 million clinical cases of malaria worldwide in 2019, and more than 400,000 people died from this disease. Although some countries have been confirmed by the WHO to ...
Views: 130 - "Super fungus" Infection Cases in ICU a Brazilian Hospital - by Submitted on Aug 04, 2021 from Jerry CarterRecently, a report published in the Journal of Fungi showed that the first cases of infection with the deadly super fungus Candida Auris (C. Auris) were found in the COVID-19 intensive care unit (ICU) of a Brazilian hospital. C. Auris ...
Views: 131 - Targeted protein degradation agent brings about another disruptive innovation - by Submitted on Aug 04, 2021 from Jerry CarterTraditional drug development strategies focus on how to treat diseases by directly regulating the activity of proteins or enzymes. Therefore, the development and application of protein activity regulators, especially inhibitors, has always been the mainstream of drug R&D. However, traditional ...
Views: 137 - Interaction Among Phage, Bacteria, and Health-1 - by Submitted on Aug 04, 2021 from Jerry CarterAs bacterial viruses, bacteriophages have been increasingly reported for their unique role in affecting bacterial diseases. Bacteriophages (https://phagenbio.creative-biolabs.com/) can directly control the composition and abundance of bacteria and indirectly affect the body's metabolism and ...
Views: 137 - Evolution of Tumor Immunotherapy: PI - by Submitted on Aug 04, 2021 from Jerry CarterIn the past few decades, immunotherapy has been at the forefront of cancer treatment. Accompanying the continuing development of tumor immunotherapy for centuries, there are many important discoverers. As early as 1777, people tried to inject various pathogens to elicit an immune response ...
Views: 189 - The evolutionary history of drug delivery - by Submitted on Aug 03, 2021 from Jerry CarterRecently, Samir Mitragotri's team published a review in Nature Biomedical Engineering, systematically summarizing five types of therapeutic drugs, which are small molecules, nucleic acids, peptides, proteins, and cells, as well as related drug delivery challenges and three measures taken to face ...
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