In the human genome, about 8% of the DNA is the remnants of retroviruses that infect humans or human ancestors in ancient times, which have become part of the human genome. Some of these sequences can even be traced back to hundreds of millions of years ago.
Previous studies have shown that ... Views: 201
Traditional drug development strategies focus on how to treat diseases by directly regulating the activity of proteins or enzymes. Therefore, the development and application of protein activity regulators, especially inhibitors, has always been the mainstream of drug R&D. However, traditional ... Views: 257
Seagne and Genmab announced on September 20, 2021 that Tisotumab Vedotin has received accelerated approval from the FDA for the treatment of recurring or metastatic cervical cancer.
Tivdak (Tisotumab vedotin-tftv) is an ADC produced by combining Genmab's tissue factor (TF) monoclonal antibody ... Views: 308
Albumin (Alb: https://www.creativebiolabs.net/symbolsearch_ALB.htm) is the most important protein in human plasma, accounting for 40%-60% of total plasma protein, which can effectively maintain body nutrition and osmotic pressure, and is closely related to human health.
Recently, a new study ... Views: 239
Most people today are immune to SARS-CoV-2, the coronavirus that causes COVID-19, thanks to widespread vaccination campaigns and unplanned infection. Although this widespread immunity hasn't stopped new infections from happening, it has slowed the devastating spread of illness and death that the ... Views: 161
Antibody-drug conjugates (ADCs) have made great progress in the past 10 years, which are a complex that has cytotoxic small-molecule drug coupled to a monoclonal antibody (mAb) through a reasonably placed linker. It can selectively deliver effective cytotoxic drugs into the tumor.
In 2009, ... Views: 285
Pit-mediated endocytosis
Clathrin-independent endocytosis includes caveolin-mediated endocytosis, caveolin-independent carrier protein/GPI-enriched early inner compartment (CLIC/GEEC), and macropinocytosis.
The pit is a vial-like invagination of the plasma membrane, characterized by high ... Views: 267
Recently, Samir Mitragotri's team published a review in Nature Biomedical Engineering, systematically summarizing five types of therapeutic drugs, which are small molecules, nucleic acids, peptides, proteins, and cells, as well as related drug delivery challenges and three measures taken to face ... Views: 278
Obesity and the gut microbiome have both been the focus of recent studies. The term "gut flora" refers to the collection of microorganisms—mostly bacteria—that inhabit the human digestive tract. Fascinatingly, bacteria make up about half of our daily fecal output and have been estimated to ... Views: 223
Zika virus (ZIKV) is a new acute viral infectious disease mainly transmitted by Aedes mosquitoes. The clinical manifestations are usually mild, but some cases may develop serious symptoms such as neurological syndrome, birth defects, or stillbirth. The first reported case of human infection was ... Views: 133
In-progress Drugs
There is an urgent need for broad-spectrum antiviral drugs to treat infections caused by emerging arboviruses. Some experts believe that one medicine for one type of vector insect is not enough to deal with outbreaks like the Zika pandemic. However, dozens of antiviral ... Views: 200
Recently, India approved a new COVID-19 vaccine, ZyCoV-D, which uses a circular DNA strand to stimulate the immune system against the SARS-CoV-2. The approval of ZyCoV-D as the world's first DNA vaccine for humans heralds the arrival of DNA vaccines against various diseases.
According to ... Views: 288
Whether it is a superhero in "The Avengers" or a vampire in "Twilight", immortality and eternal youth have always been eye-catching topics, which represent the ultimate dream of mankind. Scientists have also spent decades trying to use the power of genomics and artificial intelligence to find a ... Views: 420
Antibody-drug conjugate (ADC: https://www.creative-biolabs.com/adc/), a compound that connects a cytotoxic small-molecule drug to a monoclonal antibody via a rationally established linker, which selectively delivers an efficient cytotoxic agent into the tumor, has made significant progress in ... Views: 291
Sugar is a direct source of sweetness that not only enhances the flavor of food but also serves as a source of energy for the body. Sugar is used in everyday life to give us a "sweet" feeling, whether it's in candy, cake, or cola.
Sugar consumption is quickly increasing as material living ... Views: 268
On February 22, FiercePharma selected the 10 most anticipated new drugs on the market in 2021 based on the estimated global new drug sales data for 2026 by Evaluate Pharma. Among them, Biogen's Aducanumab, an Alzheimer's drug candidate leads the list. Other diseases such as psoriasis, KRAS G12C ... Views: 342
In 1958, Francis Crick proposed the famous "Central Dogma", thereby constructing a large framework for the transmission of biological genetic information, namely "DNA→RNA→Protein". Of course, as a theory, the central principle is often questioned and misunderstood, e.g., RNA can also be written ... Views: 274
In 1958, Francis Crick proposed the famous "Central Dogma", thereby constructing a large framework for the transmission of biological genetic information, namely "DNA→RNA→Protein". Of course, as a theory, the central principle is often questioned and misunderstood, e.g., RNA can also be written ... Views: 259
Hepatitis B virus (HBV) infection is the leading cause of global morbidity and mortality. The WHO estimates that approximately 20 million people worldwide are infected with HBV. Among those chronically infected, it is estimated that 65 million people die of liver disease due to their HBV ... Views: 266
By 2040, pancreatic ductal adenocarcinoma (PDAC) is projected to become the second most fatal kind of cancer in humans, and the majority of patients with PDAC will not respond to chemotherapy according to existing treatment protocols. Scientists have identified diet as an environmental element ... Views: 326
Influenza is a respiratory infectious disease caused by the influenza virus. About 5% to 10% of people in the world are infected with influenza every year. According to the scale, influenza epidemics can be divided into influenza pandemics and seasonal influenza epidemics. There are four main ... Views: 220
The most common neurodegenerative disease is Alzheimer's disease (AD), often known as dementia. The loss of memory, learning ability, emotional regulation, and athletic ability is common in patients, all of which have a negative impact on health, families, and society.
Currently, about 50 ... Views: 383
In the process of preclinical development, a compound or biological agent must go through the testing phases, for the following targets, which are the identification of potential targets of disease treatment and screening out the potential candidates that must go through toxicity test before ... Views: 273
Recently, many scientists around the world summarized what they have learned about Omicron (an emerging variant of SARS-CoV-2) so far, as reported in Nature.
Researchers from all over the world are now studying the Omicron strain to learn more about its infectivity, pathogenicity, and immune ... Views: 264
PDX model (full name: patient-derived tumor xenograft model) is a transplanted tumor model formed by implanting patient-derived tumor tissue and primary cells into the body of immunodeficient mice. It is usually used to assist with testing and developing anti-cancer drugs.
The PDX model ... Views: 175
PDX model (full name: patient-derived tumor xenograft model) is a transplanted tumor model formed by implanting patient-derived tumor tissue and primary cells into the body of immunodeficient mice. It is usually used to assist with testing and developing anti-cancer drugs.
The PDX model ... Views: 185
Cancer has always been one of the arch nightmares among all human diseases. It is also known as the "king of all diseases" because of its complexity and incurable nature.
In order to find a cure for cancer, scientists often cultivate various cancer cell lines in a laboratory environment and ... Views: 233
In the field of tumor therapy, antibody-drug conjugate (ADC) with both targeting and strong activities has gradually become the new focus of the industry due to its excellent performance in many indications, and it is known as "the rising star of tumor therapy".
What is ADC
Traditional ADC ... Views: 296