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Articles from Jerry Carter | Selfgrowth.com
- Revealing the mechanism by which brain cholesterol regulates beta-amyloid plaque production in Alzheimer's disease - by Submitted on Sep 06, 2021 from Jerry CarterIn a new study, researchers from the Scripps Research Institute, the University of Virginia and the University of Washington used advanced imaging methods to reveal how production of the Alzheimer's disease-associated protein amyloid beta (Aβ) in the brain is tightly regulated by ...
Views: 829 - Evolutionary Drug Delivery - by Submitted on Sep 06, 2021 from Jerry CarterDrug delivery strategies (https://www.creative-biolabs.com/targeted-delivery/) have greatly facilitated the treatment and application of drugs. The rapid development of therapeutics is dependent on the continuous pursuit of advances in delivery technologies and strategies. Decades ago, small ...
Views: 348 - Detoxification matters! After some insects fully turn on the "detox mode", they can prolong their life by 21% - by Submitted on Sep 06, 2021 from Jerry CarterProtein is an important component of all cells and tissues of the human body. However, abnormal protein activities in the body may cause problems, such as increasing the risk of cancer and making people age faster. On July 28, a research report titled "Rewiring of the ubiquitinated proteome ...
Views: 322 - Structure biology will continue to use artificial intelligence - by Submitted on Sep 02, 2021 from Jerry CarterNature issued an editorial on July 27, 2021, reflecting on recent topical reporting on AlphaFold. Our understanding of protein folding will be altered as a result of machine learning. It is important that all data be made available to the public. "I never imagined we'd make it this far in ...
Views: 380 - Clinical progress of hepatocellular carcinoma (HCC) treatment - by Submitted on Sep 02, 2021 from Jerry CarterHepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers. Globally, liver cancer is the fourth leading cause of cancer-related deaths and sixth in the number of new cases. The 5-year survival rate of liver cancer is only 18%, which is the second most lethal tumor after ...
Views: 366 - Nature: An overview of the development of antibody drugs - by Submitted on Sep 02, 2021 from Jerry CarterIt has been 35 years since the FDA approved the first monoclonal antibody in 1986. Antibody-based drugs account for nearly one-fifth of new FDA drug approvals each year. In this time, antibody engineering (https://www.creative-biolabs.com/engineering-services.html) has changed dramatically. ...
Views: 313 - Recovered patients from COVID-19 contain super antibodies against 13 natural SARS-CoV-2 variants - by Submitted on Sep 02, 2021 from Jerry CarterAs the SARS-CoV-2 continues to mutate, virus variants and associated vaccine have become the focus of attention. On August 13, a study of a team of scientists who identified super antibodies from recovered patients, published in the prestigious journal Science, found that those patients carried ...
Views: 338 - The endocytosis mechanism of ADC drugs: Part I - by Submitted on Sep 02, 2021 from Jerry CarterAntibody-drug conjugates (ADCs) have made great progress in the past 10 years, which are a complex that has cytotoxic small-molecule drug coupled to a monoclonal antibody (mAb) through a reasonably placed linker. It can selectively deliver effective cytotoxic drugs into the tumor. In 2009, ...
Views: 384 - Interaction Among Phage, Bacteria, and Health - by Submitted on Aug 28, 2021 from Jerry CarterWhat are the effects of bacteriophages on the body's immune system? Bacteriophages cannot infect eukaryotic cells, but more and more studies have shown that phages can regulate the immune response of mammals. Especially when the phage and the host bacteria ...
Views: 323 - Evolution of Tumor Immunotherapy: PII - by Submitted on Aug 28, 2021 from Jerry CarterAnti-tumor Monoclonal Antibody (mAb) The concept that cancer cells express certain potential target antigens paves the way for humanized antibodies as a therapeutic strategy for malignant tumors. Antibodies can interact with immune cells through the Fc domain of antibodies to target and destroy ...
Views: 356 - Live Vaccines Against Malaria - by Submitted on Aug 04, 2021 from Jerry CarterFor a long time, malaria is one of the most serious diseases threatening human health. According to the WHO, there were 229 million clinical cases of malaria worldwide in 2019, and more than 400,000 people died from this disease. Although some countries have been confirmed by the WHO to ...
Views: 339 - "Super fungus" Infection Cases in ICU a Brazilian Hospital - by Submitted on Aug 04, 2021 from Jerry CarterRecently, a report published in the Journal of Fungi showed that the first cases of infection with the deadly super fungus Candida Auris (C. Auris) were found in the COVID-19 intensive care unit (ICU) of a Brazilian hospital. C. Auris ...
Views: 322 - Targeted protein degradation agent brings about another disruptive innovation - by Submitted on Aug 04, 2021 from Jerry CarterTraditional drug development strategies focus on how to treat diseases by directly regulating the activity of proteins or enzymes. Therefore, the development and application of protein activity regulators, especially inhibitors, has always been the mainstream of drug R&D. However, traditional ...
Views: 328 - Interaction Among Phage, Bacteria, and Health-1 - by Submitted on Aug 04, 2021 from Jerry CarterAs bacterial viruses, bacteriophages have been increasingly reported for their unique role in affecting bacterial diseases. Bacteriophages (https://phagenbio.creative-biolabs.com/) can directly control the composition and abundance of bacteria and indirectly affect the body's metabolism and ...
Views: 347 - Evolution of Tumor Immunotherapy: PI - by Submitted on Aug 04, 2021 from Jerry CarterIn the past few decades, immunotherapy has been at the forefront of cancer treatment. Accompanying the continuing development of tumor immunotherapy for centuries, there are many important discoverers. As early as 1777, people tried to inject various pathogens to elicit an immune response ...
Views: 392 - The evolutionary history of drug delivery - by Submitted on Aug 03, 2021 from Jerry CarterRecently, Samir Mitragotri's team published a review in Nature Biomedical Engineering, systematically summarizing five types of therapeutic drugs, which are small molecules, nucleic acids, peptides, proteins, and cells, as well as related drug delivery challenges and three measures taken to face ...
Views: 375 - AstraZeneca/Daiichi Sankyo launched phase III clinical study of antibody conjugate (ADC) Enhertu targeting HER2! - by Submitted on Aug 03, 2021 from Jerry CarterDaiichi Sankyo and AstraZeneca recently announced that in the global phase 3 clinical trial—DESTINY-The Gastric04 (NCT04704934), the first patient was given a drug treatment to evaluate the HER2-targeting ADC (https://www.creative-biolabs.com/adc/target-erbb2-37.htm) Enhertu (fam-trastuzumab ...
Views: 308 - New discovery on cancer cell membrane makes it possible to inhibit cancer cell proliferation! - by Submitted on Aug 03, 2021 from Jerry CarterThe development of new cancer therapy is based on the discovery of new characteristics and weaknesses of cancer cells. A group of Danish researchers found another characteristic of cancer cells through experiments on cancer cell membranes, that is, cancer cells constantly repair their own cell ...
Views: 301 - The amazing protein in the blood! - by Submitted on Aug 03, 2021 from Jerry CarterAlbumin (Alb: https://www.creativebiolabs.net/symbolsearch_ALB.htm) is the most important protein in human plasma, accounting for 40%-60% of total plasma protein, which can effectively maintain body nutrition and osmotic pressure, and is closely related to human health. Recently, a new study ...
Views: 337 - RNA Therapy—Center of Next-generation Innovative Therapies: Chapter II - by Submitted on Aug 03, 2021 from Jerry CarterThere are three key points in RNA drug R&D. First, the immunogenicity of RNA drugs: Because foreign RNA will be recognized by the immune system as a signal of virus interference, RNA drugs will more or less stimulate the immune system and cause a series of side effects. Second, the ...
Views: 271 - Cancer Neoantigen Vaccine R&D Contributes to Personalized Medicine - by Submitted on Jul 05, 2021 from Jerry CarterVaccines have traditionally been used to prevent infectious diseases, whose ability to induce and amplify antigen-specific immune responses has long been considered a potentially valuable tool for the treatment of cancer. Early therapeutic vaccination strategies focused on the abnormally ...
Views: 314 - Why are the results of cancer cell experiments always "different"? Cancer cells in a petri dish have nothing in common with cancer cells in the human body - by Submitted on Jul 05, 2021 from Jerry CarterCancer has always been one of the arch nightmares among all human diseases. It is also known as the "king of all diseases" because of its complexity and incurable nature. In order to find a cure for cancer, scientists often cultivate various cancer cell lines in a laboratory environment and ...
Views: 312 - Design and optimization of PROTAC linking groups - by Submitted on Jul 05, 2021 from Jerry CarterSince the first proof of concept in 2001, targeted protein degradation induced by small molecules has gradually become a popular direction in drug development. There are two main strategies for inducing degradation. One is to use small molecules that can change the E3 ligase substrate ...
Views: 312 - RNA Therapy—Center of Next-generation Innovative Therapies: Chapter I - by Submitted on Jul 05, 2021 from Jerry CarterRNA drugs directly interfere with the process of gene transcription and translation, the essence of which is gene therapy. Traditional gene therapy in a narrow sense generally refers to directly modifying the disease-causing genes of target cells or introducing foreign copies of normal genes. ...
Views: 270 - Challenges of Phage Therapy - by Submitted on Jul 04, 2021 from Jerry CarterIn this era of "superbugs" floods, phage therapy has re-entered public vision. Although there have been many cases of patients with "superbugs" infection being cured by phage, there are still some challenges in phage therapy. Quality and safety requirements The success of phage therapy ...
Views: 311 - The most comprehensive analysis to date: Due to biological limitations, humans cannot slow down the rate of aging - by Submitted on Jul 04, 2021 from Jerry CarterWhether it is a superhero in "The Avengers" or a vampire in "Twilight", immortality and eternal youth have always been eye-catching topics, which represent the ultimate dream of mankind. Scientists have also spent decades trying to use the power of genomics and artificial intelligence to find a ...
Views: 502 - How are "Human-like" Antibodies Obtained? - by Submitted on Jul 04, 2021 from Jerry CarterThe most commonly used murine monoclonal antibodies (mAbs) have played a crucial role in clinical diagnosis and treatment, which, however, have strong immunogenicity and can cause human anti-mouse antibody (HAMA) reactions in clinical applications, resulting in shorter antibody half-life (less ...
Views: 452 - A Novel Type of Immunotherapy May Eliminate All Advanced Tumor Cells - by Submitted on Jul 04, 2021 from Jerry CarterImmunotherapy (https://www.creative-biolabs.com/immuno-oncology/) has gained full attention around the world, which gradually becomes the mainstream cancer treatment. As the key executor of the downstream effects of the immune response, macrophages play an important role in the immune response ...
Views: 307 - Monoclonal Antibody (mAb) Therapy Against COVID-19 - by Submitted on Jul 04, 2021 from Jerry CarterSARS-CoV-2 (https://www.antibody-creativebiolabs.com/search.aspx?key=sars-cov-2&ty=product) swept the world in 2020, leading to blockades, social distancing, and huge economic losses. In addition, COVID-19 also triggered vaccine, treatment, and diagnostics competition, achieving the approval of ...
Views: 720 - ADCs Against Lung Cancer: PII - by Submitted on Jun 09, 2021 from Jerry CarterADC targeting Trop-2 Trophoblast cell surface antigen 2 (Trop-2) is a transmembrane glycoprotein encoded by the tumor-associated calcium signal transducer 2 (TACSTD2) gene located in the 1p32 region of chromosome, and is a new target for the treatment of solid tumors. It acts as a calcium ...
Views: 276 - Antibody screening technologies applied in innovative antibody discovery: PII - by Submitted on Jun 09, 2021 from Jerry CarterAntibody Library According to the source and use of antibody genes, antibody libraries are divided into immune antibody library (https://www.creative-biolabs.com/immune-antibody-library-services.html) and general antibody library. The antibody genes of the immune antibody library are derived ...
Views: 282 - New Approaches to Treating Neurological Diseases - by Submitted on Jun 09, 2021 from Jerry CarterA team led by medical researchers at Case Western Reserve University has developed a potential treatment for Perizois-metzbach's disease (PMD). It is a fatal neurological disease caused by genetic mutations that prevent the body from producing myelin, which is a protective insulator around nerve ...
Views: 293 - Breakthrough! A new target for pancreatic cancer treatment - by Submitted on Jun 02, 2021 from Jerry CarterPancreatic cancer is a highly malignant tumor of the digestive tract that is difficult to diagnose and treat. 90% of the subtypes are pancreatic ductal adenocarcinoma (PDAC). In recent years, the incidence and mortality of pancreatic cancer have increased significantly. The early diagnosis ...
Views: 303 - Novel PROTAC, SPNpro - by Submitted on Jun 02, 2021 from Jerry CarterImmunometabolism involves glycolysis, tricarboxylic acid cycle, and pentose phosphate pathway and amino acid metabolism and other intracellular metabolic pathways, which play a vital role in regulating immune cell responses. In particular, the metabolism of amino acids such as tryptophan (Trp), ...
Views: 285 - Comparison Between Phage Display Antibody Library and Hybridoma - by Submitted on Jun 02, 2021 from Jerry CarterAs commonly used antibody screening technologies, hybridomas and phage display (https://phagenbio.creative-biolabs.com/phage-display-systems.htm) libraries have their own characteristics. The heavy chain and light chain of hybridoma mAbs derive from a B cell, which is a natural pairing. The ...
Views: 276 - mRNA technology, not only plays a part in the COVID-19 vaccine but also in cancer therapeutics - by Submitted on Jun 01, 2021 from Jerry CarterIn the emergency response to the COVID-19 epidemic, the first vaccines to be released are all based on mRNA technology. Recently, the "double mutation" mutant virus appeared in India, and mRNA vaccine has once again been highlighted due to its short research cycle. Only a year ago, mRNA was ...
Views: 277 - Surprising: An ancient virus hidden in the human genome provides a new target for esophageal cancer treatment - by Submitted on Jun 01, 2021 from Jerry CarterIn the human genome, about 8% of the DNA is the remnants of retroviruses that infect humans or human ancestors in ancient times, which have become part of the human genome. Some of these sequences can even be traced back to hundreds of millions of years ago. Previous studies have shown that ...
Views: 287 - Antibody screening technologies applied in innovative antibody discovery: PI - by Submitted on Jun 01, 2021 from Jerry CarterAntibody discovery includes two procedures, antibody screening and optimization. Antibody screening is to search for high-quality antibody candidates from the beginning, and antibody optimization is to make necessary improvements to existing antibodies. Antibody discovery is the only way to ...
Views: 253 - Can HER3 Become a Therapeutic Target? - by Submitted on Jun 01, 2021 from Jerry CarterWith the increasingly fierce competition in the field of oncology drug R&D, the exploration of various drug forms based on established drug targets is a relatively low-risk R&D option. However, the commercialized drug targets that have been successfully operated are already very competitive. ...
Views: 275 - ADCs Against Lung Cancer: PI - by Submitted on Jun 01, 2021 from Jerry CarterIn recent years, nanotechnology and nanotherapy have exerted a profound impact on many fields of medicine, of which the biggest contribution in cancer is mainly derived from the development of new drug delivery systems, including liposomes, nanoparticles, and antibody-drug conjugates (ADCs). ...
Views: 254 - The Fight Against Zika: PII - by Submitted on May 27, 2021 from Jerry CarterIn-progress Drugs There is an urgent need for broad-spectrum antiviral drugs to treat infections caused by emerging arboviruses. Some experts believe that one medicine for one type of vector insect is not enough to deal with outbreaks like the Zika pandemic. However, dozens of antiviral ...
Views: 283 - The Fight Against Zika: PI - by Submitted on May 26, 2021 from Jerry CarterZika virus (ZIKV) is a new acute viral infectious disease mainly transmitted by Aedes mosquitoes. The clinical manifestations are usually mild, but some cases may develop serious symptoms such as neurological syndrome, birth defects, or stillbirth. The first reported case of human infection was ...
Views: 219 - Clinical Progress of Anti-SARS-CoV-2 Neutralizing Antibody (NAb)—PART III - by Submitted on May 26, 2021 from Jerry CarterIn this article, we'll continue talking about the nAb drugs that have entered clinical trial. REGN-COV2 REGN-COV2 is a new type of mixture composed of two mAbs (REGN10987 and REGN10933, recently named imdevimab and casirivimab, respectively) for the treatment of COVID-19 patients and the ...
Views: 237 - Progress! A Potential Drug to Treat Alzheimer's Disease (AD) - by Submitted on May 05, 2021 from Jerry CarterAlzheimer's disease is a neurodegenerative disease with insidious onset and progressive development, of which the clinical features are mainly cognitive impairment, abnormal mental behavior, and decline in social life function. Generally, early onset usually occurs before the age of 65. A family ...
Views: 276 - Clinical Progress of Anti-SARS-CoV-2 Neutralizing Antibody (NAb)—PART II - by Submitted on May 05, 2021 from Jerry CarterIn this article, we'll continue talking about the nAb drugs that have entered the clinical trials. LY-CoV555 and LY-CoV016 LY-CoV555 (also known as LY3819253, recently named bamlanivimab) is a fully human neutralizing IgG1 mAb developed by AbCellera and the National Institute of Allergy ...
Views: 294 - Why are many anti-cancer drugs effective in animals, but mediocre in humans? - by Submitted on Apr 28, 2021 from Jerry CarterPDX model (full name: patient-derived tumor xenograft model) is a transplanted tumor model formed by implanting patient-derived tumor tissue and primary cells into the body of immunodeficient mice. It is usually used to assist with testing and developing anti-cancer drugs. The PDX model ...
Views: 248 - Why are many anti-cancer drugs effective in animals, but mediocre in humans? - by Submitted on Apr 28, 2021 from Jerry CarterPDX model (full name: patient-derived tumor xenograft model) is a transplanted tumor model formed by implanting patient-derived tumor tissue and primary cells into the body of immunodeficient mice. It is usually used to assist with testing and developing anti-cancer drugs. The PDX model ...
Views: 240 - Up-to-date Progress in the R&D of Anti-influenza Vaccines - by Submitted on Apr 28, 2021 from Jerry CarterInfluenza is a respiratory infectious disease caused by the influenza virus. About 5% to 10% of people in the world are infected with influenza every year. According to the scale, influenza epidemics can be divided into influenza pandemics and seasonal influenza epidemics. There are four main ...
Views: 298 - Released! Molecule Structure of ARV110 and ARV471 - by Submitted on Apr 28, 2021 from Jerry CarterA few days ago, Arvinas, which is committed to developing targeted protein degradation therapies, announced at the American Association for Cancer Research (AACR) annual meeting the molecular structure and pharmacochemical optimization process of two PROTAC based therapies entering the clinical ...
Views: 323 - Clinical Progress of Anti-SARS-CoV-2 Neutralizing Antibody (NAb)—PART I - by Submitted on Apr 28, 2021 from Jerry CarterCurrently, the number of COVID-19 confirmed cases has exceeded 147 million, and the death exceeded 2 million. The rapid spread of COVID-19 prompts the healthcare community to explore potential treatments, by investigating the drugs that are already approved and developing innovative therapies ...
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