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Articles from Jerry Carter | Selfgrowth.com
- Breaking News! The Release of COVID-19 Vaccine Gene Sequence - by Submitted on Apr 28, 2021 from Jerry CarterRecently, scientists at Stanford University published a gene sequencing file of Moderna's COVID-19 vaccine on the open-source code repository GitHub, deciphering the mRNA sequence of the vaccine for the first time. The release immediately captured the headlines of major science and technology ...
Views: 696 - New Approaches to Coping with the Damage to Kidneys Caused by Excessive Intake of Processed Foods - by Submitted on Apr 28, 2021 from Jerry CarterA huge population consume large amounts of ready-to-eat foods such as bread, biscuits, and various snacks every day, which have been highly or overly heat-processed. During the processing, the chemical structure of the food is changed, thereby prolonging their shelf life, palatability, and ...
Views: 256 - Understand the Hepatitis B - by Submitted on Apr 01, 2021 from Jerry CarterHepatitis B virus (HBV) infection is the leading cause of global morbidity and mortality. The WHO estimates that approximately 20 million people worldwide are infected with HBV. Among those chronically infected, it is estimated that 65 million people die of liver disease due to their HBV ...
Views: 322 - What is Preclinical Testing? - by Submitted on Apr 01, 2021 from Jerry CarterIn the process of preclinical development, a compound or biological agent must go through the testing phases, for the following targets, which are the identification of potential targets of disease treatment and screening out the potential candidates that must go through toxicity test before ...
Views: 328 - PROTAC In Focus—Hotspot Targets Under Research - by Submitted on Apr 01, 2021 from Jerry CarterPROTAC is a novel type of drug that is different from antibodies and traditional small molecule inhibitors, consisting of a linker and two warheads. One end of the PROTAC molecule binds to the target protein, and the other binds to the E3 ubiquitin ligase that can mark the target protein as ...
Views: 272 - Blockbuster—Rhesus Monkeys Produce Similar Immune Responses to Humans Against HCV - by Submitted on Apr 01, 2021 from Jerry CarterResearchers such as Mansun Law of The Scripps Research Institute discovered that rhesus monkeys can produce a convergent antibody response to HCV envelope glycoprotein. The paper entitled "Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques ...
Views: 304 - Booster of Antibody Drug Discovery—Phage Display Library Technology - by Submitted on Apr 01, 2021 from Jerry CarterPhage display technology is a powerful gene expression screening technology, which was first described by SmithMl et al. in Science in 1985. The basic principle is to clone the gene of the foreign protein into the genomic DNA of the phage, thereby expressing the specific foreign protein on the ...
Views: 272 - 40 Billion USD Transactions, ADC Drugs Have Unlimited Potential - by Submitted on Apr 01, 2021 from Jerry Carter10 ADC drugs have been approved by the FDA for the treatment of various cancers including hematological tumors and solid tumors in a decade since 2010. Of the 10 ADC drugs currently on the market, 7 have been approved in the last three or four years. Such intensive approval has made ADC the ...
Views: 233 - New Modes of Antibody Drug Coupling—PDC, AOC, ABC, AAC, ISAC - by Submitted on Mar 26, 2021 from Jerry CarterIn recent years, antibody drugs have undergone explosive development and occupied an increasing proportion in the market of drugs. The high specific affinity of monoclonal antibody against tumor cell antigen making it an ideal carrier for targeted drug delivery, which can be used to target ...
Views: 332 - Collagen Lose Accelerates Cancer Development - by Submitted on Mar 26, 2021 from Jerry CarterCollagen is the most abundant protein in the human body, which is produced by fibroblasts and exists in bones, tendons, and skin. During the occurrence and development of cancer, collagen tends to accumulate in and around tumors. Therefore, some researchers speculate that collagen helps to ...
Views: 298 - Explore into Pharmacokinetics/pharmacodynamics (PK/PD) of Antibody Drugs - by Submitted on Mar 26, 2021 from Jerry CarterIn the past few decades, both pharmaceutical companies and academia have spent much financial resources and energy to improve the practicability and accuracy of in vitro screening technology that can test the biological activity and physicochemical properties of compounds. However, the study of ...
Views: 257 - 10 Q&As About Monoclonal Antibody (mAb) - by Submitted on Mar 26, 2021 from Jerry CarterMonoclonal antibodies, mRNA/DNA vaccines, CAR-T cells, etc., are popular biological products nowadays, which play an important role in disease prevention and treatment. Most of these technologies originated in the 1980s, which are independent of each other and developed in concert to jointly ...
Views: 345 - Anti-HBV Drugs in Progress - by Submitted on Mar 26, 2021 from Jerry CarterHBV (https://www.creativebiolabs.net/symbolsearch_HBV.htm) generates free covalently closed circular DNA (cccDNA) and exists in the nucleus of infected cells, which is the only known pregenomic RNA (pgRNA) template, as well as a template for viral protein transcription and viral replication. As ...
Views: 302 - 10 Landmark Drugs in Human History - by Submitted on Mar 02, 2021 from Jerry CarterPenicillin is an important antibiotic with high efficiency, low toxicity, and wide clinical application. At the beginning of the 20th century, there were no drug to treat bacterial infections with low side effects. By chance, the British biochemist Alexander Fleming discovered penicillin. In ...
Views: 383 - Stroke Cats Happily and Stay Away from Allergies - by Submitted on Mar 02, 2021 from Jerry CarterFor cat lovers, the most tragic thing is probably the cat allergy. As soon as you get close to the cat, you sneeze, have a runny nose, or itchy eyes, skin rashes, and even asthma attacks. There are many people who are allergic to cats, with about 1 in 10 in the population. In some areas, as ...
Views: 305 - 2020, the First Era of mRNA Therapy - by Submitted on Mar 02, 2021 from Jerry CarterCOVID-19 ravaged the world and caused huge losses to human society, but it has accelerated the research and development of mRNA drugs. Some people call 2020 "the first year of mRNA technology." Progress in mRNA drug development In 1990, Wolff et al. demonstrated for the first time that ...
Views: 323 - Ebola Comes Back, Another Blow Under the COVID-19 Epidemic - by Submitted on Mar 02, 2021 from Jerry CarterRecently, when most countries in the world are still struggling with the COVID-19, the Ebola virus (EBOV) that is more deadly, resurfaced. According to UN News, a funeral was held on February 1 after the death of a nurse in southern Guinea, West Africa, on January 28. Unfortunately, the 6 ...
Views: 312 - Emerging SARS-CoV-2 Mutants - by Submitted on Mar 02, 2021 from Jerry CarterSince the start of the COVID-19 pandemic in early 2020, a series of variants of the SARS-CoV-2 have emerged around the world. In the early stages of the epidemic, a new coronavirus containing a mutation in the spike protein D614G dominated the world. The scientific community generally believes ...
Views: 356 - Top 10 Most Anticipated New Drugs in 2021 - by Submitted on Mar 02, 2021 from Jerry CarterOn February 22, FiercePharma selected the 10 most anticipated new drugs on the market in 2021 based on the estimated global new drug sales data for 2026 by Evaluate Pharma. Among them, Biogen's Aducanumab, an Alzheimer's drug candidate leads the list. Other diseases such as psoriasis, KRAS G12C ...
Views: 394 - A Quick Look at ADC—A New Favorite of Cancer Treatment - by Submitted on Feb 23, 2021 from Jerry CarterTraditional chemotherapeutics work by killing actively growing cells, but cannot accurately identify tumor cells. Therefore, when the tumor cells are killed, normal cells are also destroyed, resulting in larger adverse reactions. With the development of modern medicine, traditional extensive ...
Views: 314 - Novel Therapeutics for Hepatitis B - by Submitted on Feb 23, 2021 from Jerry CarterHepatitis B virus (HBV) infects around 257 to 291 million people worldwide. The liver is vital to the health of the human body. Excessive drinking, drugs, medicines, and other viruses can cause damage to the liver. Once the liver is damaged, it will not function properly and people will ...
Views: 849 - Can JNJ's One-dose COVID-19 Vaccine Draw the Curtain? - by Submitted on Feb 23, 2021 from Jerry CarterJohnson & Johnson announced the Phase 3 ENSEMBLE clinical trial data of topline efficacy and safety, demonstrating that the investigational single-dose COVID-19 vaccine developed by Janssen met all primary and key secondary endpoints. The data are based on 43,783 participants accruing 468 ...
Views: 367 - 100 Million Confirmed Cases of COVID-19 - by Submitted on Feb 03, 2021 from Jerry CarterAccording to real-time data from Johns Hopkins University, as of January 25, the total number of confirmed cases of COVID-19 around the world was 99.269 million, with 25.128 million in the United States, India ranking second with 10.668 million, accounting for 25.3% and 10.7% individually of ...
Views: 356 - Immunogenicity of Antibody Drugs - by Submitted on Feb 03, 2021 from Jerry CarterThe advent of the era of precision medicine takes monoclonal antibody (mAb) drugs that have high specificity and effectiveness to a hot spot in biological drug therapy. In 1975, Georges Köhler and César Milstein successfully invented hybridoma technology, laying the foundation for monoclonal ...
Views: 322 - Overview of Anti-HIV Drugs - by Submitted on Feb 02, 2021 from Jerry CarterAIDS, Acquired Immune Deficiency Syndrome, is a malignant infectious disease with a very high fatality rate caused by HIV (human immunodeficiency virus). HIV invades the human body and can destroy the human immune system, causing the infected person to gradually lose the ability to resist ...
Views: 407 - Opportunities and Challenges of IVD - by Submitted on Feb 02, 2021 from Jerry CarterThe outbreak of the COVID-19 epidemic in 2020 brought unprecedented attention to the in vitro diagnostics (IVD) industry. At present, there are two main types of detection products for COVID-19 used internationally, which are molecular diagnosis (nucleic acid detection) and immunodiagnosis ...
Views: 353 - Organoid—Improve Disease Research and Drug Development - by Submitted on Feb 02, 2021 from Jerry CarterOrganoids, 3D "micro-organ models" that are prepared from different types of stem cells through self-organization, can simulate the structure and function of native organs. Organoids represent an innovative technology that covers the physiological processes of the entire organism, having a ...
Views: 240 - Why Is ADC the "Rising Star of Cancer Treatment"? - by Submitted on Feb 02, 2021 from Jerry CarterIn the field of tumor therapy, antibody-drug conjugate (ADC) with both targeting and strong activities has gradually become the new focus of the industry due to its excellent performance in many indications, and it is known as "the rising star of tumor therapy". What is ADC Traditional ADC ...
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